Most glomerulonephritides, even the more common types, are rare diseases. They are
nevertheless important since they frequently affect young people, often cannot be cured, and …

This review discusses the causes, pathogenesis, and clinical management of
membranoproliferative glomerulonephritis, which accounts for 7 to 10% of biopsy-confirmed …

Glomerular disease, be it primary or secondary, occurring in the setting of systemic
autoimmune diseases, infections, drugs, or malignancy, affects individuals of all ages. In …

C3 glomerulonephritis (C3GN) is a recently described disorder that typically results from
abnormalities in the alternative pathway (AP) of complement. Here, we describe the clinical …

Glomerulonephritis (GN) is an important cause of morbidity and mortality in patients of all
ages throughout the world. Because these disorders are relatively rare, it is difficult to …

Factor H related proteins comprise a group of five plasma proteins: CFHR1, CFHR2,
CFHR3, CFHR4 and CFHR5, and each member of this group binds to the central …

A kidney biopsy is done to determine the etiology of the glomerulonephritis (GN) and the
severity of the lesion, to identify whether other lesions, related to or not related to the GN, are …

Precise immunofluorescence criteria for C3 glomerulopathy remain to be defined. Here we
tested hierarchical immunofluorescence criteria with varying stringency for C3 …

Background Membranoproliferative glomerulonephritis (MPGN) is an uncommon cause of
chronic nephropathy recently reclassified into immunoglobulin-associated MPGN (Ig-MPGN) …

Membranoproliferative GN (MPGN) was recently reclassified as alternative pathway
complement–mediated C3 glomerulopathy (C3G) and immune complex–mediated …