The Lectin Pathway of the Complement System—Activation, Regulation, Disease Connections and Interplay with Other (Proteolytic) Systems
The complement system is the other major proteolytic cascade in the blood of vertebrates
besides the coagulation–fibrinolytic system. Among the three main activation routes of …
besides the coagulation–fibrinolytic system. Among the three main activation routes of …
The Relationship between Complements and Age‐Related Macular Degeneration and Its Pathogenesis
L Chu, C Bi, C Wang, H Zhou - Journal of Ophthalmology, 2024 - Wiley Online Library
Age‐related macular degeneration is a retinal disease that causes permanent loss of central
vision in people over the age of 65. Its pathogenesis may be related to mitochondrial …
vision in people over the age of 65. Its pathogenesis may be related to mitochondrial …
[HTML][HTML] Genetic investigation of Nordic patients with complement-mediated kidney diseases
V Rydberg, SS Aradottir, AC Kristoffersson… - Frontiers in …, 2023 - frontiersin.org
Background Complement activation in atypical hemolytic uremic syndrome (aHUS), C3
glomerulonephropathy (C3G) and immune complex-mediated membranoproliferative …
glomerulonephropathy (C3G) and immune complex-mediated membranoproliferative …
Cadmium-associated protein changes in residents of contaminated areas: Abandoned mine and smelter
S Mun, YR Lee, J Lee, S Lee, Y Yun, J Kim… - Environmental …, 2024 - Elsevier
Cadmium (Cd), a serious environmental contaminant, is associated with adverse health
effects. However, the specific changes that the human body experiences in response to …
effects. However, the specific changes that the human body experiences in response to …
[HTML][HTML] Complement factor I: Regulatory nexus, driver of immunopathology, and therapeutic
TM Hallam, SJ Sharp, A Andreadi, D Kavanagh - Immunobiology, 2023 - Elsevier
Complement factor I (FI) is the nexus for classical, lectin and alternative pathway
complement regulation. FI is an 88kDa plasma protein that circulates in an inactive …
complement regulation. FI is an 88kDa plasma protein that circulates in an inactive …
[HTML][HTML] Increased end-stage renal disease risk in age-related macular degeneration: a nationwide cohort study with 10-year follow-up
Common etiologies between age-related macular degeneration (AMD) and kidney disease
advocate a close link between AMD and end-stage renal disease (ESRD). However, the risk …
advocate a close link between AMD and end-stage renal disease (ESRD). However, the risk …
[HTML][HTML] Functional evaluation of complement factor I variants by immunoassays and SDS-PAGE
A Gerogianni, LM Baas, DJ Sjöström… - Frontiers in …, 2023 - frontiersin.org
Factor I (FI) is an essential regulator of the complement system. Together with co-factors, FI
degrades C3b, which inhibits further complement activation. Genetic mutations in FI are …
degrades C3b, which inhibits further complement activation. Genetic mutations in FI are …
Variants in complement genes are uncommon in patients with anti-factor H autoantibody-associated atypical hemolytic uremic syndrome
P Khandelwal, A Joshi, A Mathur, M Puraswani… - Pediatric …, 2023 - Springer
Background Coexisting genetic variants in patients with anti-factor H (FH)-associated
atypical hemolytic uremic syndrome (aHUS) have implications for therapy. We estimated the …
atypical hemolytic uremic syndrome (aHUS) have implications for therapy. We estimated the …
[HTML][HTML] A novel method for real-time analysis of the complement C3b:FH:FI complex reveals dominant negative CFI variants in age-related macular degeneration
TM Hallam, TE Cox, K Smith-Jackson… - Frontiers in …, 2022 - frontiersin.org
Age-related macular degeneration (AMD) is linked to 2 main disparate genetic pathways: a
chromosome 10 risk locus and the alternative pathway (AP) of complement. Rare genetic …
chromosome 10 risk locus and the alternative pathway (AP) of complement. Rare genetic …
[HTML][HTML] An assessment of prevalence of Type 1 CFI rare variants in European AMD, and why lack of broader genetic data hinders development of new treatments …
Purpose Advanced age-related macular degeneration (AAMD) risk is associated with rare
complement Factor I (FI) genetic variants associated with low FI protein levels (termed 'Type …
complement Factor I (FI) genetic variants associated with low FI protein levels (termed 'Type …