[HTML][HTML] Complement system part II: role in immunity
NS Merle, R Noe, L Halbwachs-Mecarelli… - Frontiers in …, 2015 - frontiersin.org
The complement system has been considered for a long time as a simple lytic cascade,
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …
The immune system and kidney disease: basic concepts and clinical implications
C Kurts, U Panzer, HJ Anders, AJ Rees - Nature Reviews Immunology, 2013 - nature.com
The kidneys are frequently targeted by pathogenic immune responses against renal
autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent …
autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent …
[HTML][HTML] C3 glomerulopathy: consensus report
MC Pickering, VD D'agati, CM Nester, RJ Smith… - Kidney international, 2013 - Elsevier
C3 glomerulopathy is a recently introduced pathological entity whose original definition was
glomerular pathology characterized by C3 accumulation with absent or scanty …
glomerular pathology characterized by C3 accumulation with absent or scanty …
[HTML][HTML] Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies
A Servais, LH Noël, LT Roumenina, M Le Quintrec… - Kidney international, 2012 - Elsevier
Dense deposit disease and glomerulonephritis with isolated C3 deposits are
glomerulopathies characterized by deposits of C3 within or along the glomerular basement …
glomerulopathies characterized by deposits of C3 within or along the glomerular basement …
Complement and its receptors: new insights into human disease
VM Holers - Annual review of immunology, 2014 - annualreviews.org
Although new activation and regulatory mechanisms are still being identified, the basic
architecture of the complement system has been known for decades. Two major roles of …
architecture of the complement system has been known for decades. Two major roles of …
Membranoproliferative glomerulonephritis—a new look at an old entity
S Sethi, FC Fervenza - New England Journal of Medicine, 2012 - Mass Medical Soc
This review discusses the causes, pathogenesis, and clinical management of
membranoproliferative glomerulonephritis, which accounts for 7 to 10% of biopsy-confirmed …
membranoproliferative glomerulonephritis, which accounts for 7 to 10% of biopsy-confirmed …
Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies
J Zuber, F Fakhouri, LT Roumenina, C Loirat… - Nature Reviews …, 2012 - nature.com
In the past decade, a large body of evidence has accumulated in support of the critical role
of dysregulation of the alternative complement pathway in atypical haemolytic uraemic …
of dysregulation of the alternative complement pathway in atypical haemolytic uraemic …
Eculizumab for dense deposit disease and C3 glomerulonephritis
Results The subjects included three patients with dense deposit disease (including one
patient with recurrent dense deposit disease in allograft) and three patients with C3 …
patient with recurrent dense deposit disease in allograft) and three patients with C3 …
[HTML][HTML] C3 glomerulonephritis: clinicopathological findings, complement abnormalities, glomerular proteomic profile, treatment, and follow-up
S Sethi, FC Fervenza, Y Zhang, L Zand, JA Vrana… - Kidney international, 2012 - Elsevier
C3 glomerulonephritis (C3GN) is a recently described disorder that typically results from
abnormalities in the alternative pathway (AP) of complement. Here, we describe the clinical …
abnormalities in the alternative pathway (AP) of complement. Here, we describe the clinical …
An overview of inflammation: mechanism and consequences
AU Ahmed - Frontiers in Biology, 2011 - Springer
Inflammation is an essential response provided by the immune systems that ensures the
survival during infection and tissue injury. Inflammatory responses are essential for the …
survival during infection and tissue injury. Inflammatory responses are essential for the …