[HTML][HTML] The role of the gut microbiome in eye diseases

DC Zysset-Burri, S Morandi, EL Herzog… - Progress in retinal and …, 2023 - Elsevier
The gut microbiome is a complex ecosystem of microorganisms and their genetic entities
colonizing the gastrointestinal tract. When in balanced composition, the gut microbiome is in …

Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration

K Bharti, AI den Hollander, A Lakkaraju, D Sinha… - Experimental eye …, 2022 - Elsevier
Age-related macular degeneration (AMD) is a disease that affects the macula–the central
part of the retina. It is a leading cause of irreversible vision loss in the elderly. AMD onset is …

[HTML][HTML] The retinal pigmentation pathway in human albinism: Not so black and white

R Bakker, EL Wagstaff, CC Kruijt, E Emri… - Progress in retinal and …, 2022 - Elsevier
Albinism is a pigment disorder affecting eye, skin and/or hair. Patients usually have
decreased melanin in affected tissues and suffer from severe visual abnormalities, including …

Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration

Y Pan, Y Fu, PN Baird, RH Guymer, T Das… - Progress in Retinal and …, 2023 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of severe irreversible central
vision loss in individuals over 65 years old. Genome-wide association studies (GWASs) …

[HTML][HTML] Bruch's membrane: a key consideration with complement-based therapies for age-related macular degeneration

S Hammadi, N Tzoumas, M Ferrara… - Journal of Clinical …, 2023 - mdpi.com
The complement system is crucial for immune surveillance, providing the body's first line of
defence against pathogens. However, an imbalance in its regulators can lead to …

[HTML][HTML] Inflammation and retinal degenerative diseases

G Kaur, NK Singh - Neural Regeneration Research, 2023 - journals.lww.com
Vision is an ability that depends on the precise structure and functioning of the retina. Any
kind of stress or injury can disrupt the retinal architecture and leads to vision impairment …

Age‐related macular degeneration: A disease of extracellular complement amplification

S de Jong, J Tang, SJ Clark - Immunological reviews, 2023 - Wiley Online Library
Age‐related macular degeneration (AMD) is a major cause of vision impairment in the
Western World, and with the aging world population, its incidence is increasing. As of today …

[HTML][HTML] Exudative versus nonexudative age-related macular degeneration: physiopathology and treatment options

AR Fernandes, A Zielińska, E Sanchez-Lopez… - International journal of …, 2022 - mdpi.com
Age-related macular degeneration (AMD) is an eye disease typically associated with the
aging and can be classified into two types—namely, the exudative and the nonexudative …

[HTML][HTML] Proteomics profiling of vitreous humor reveals complement and coagulation components, adhesion factors, and neurodegeneration markers as discriminatory …

FM Santos, S Ciordia, J Mesquita, C Cruz… - Frontiers in …, 2023 - frontiersin.org
Introduction Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are
leading causes of visual impairment and blindness in people aged 50 years or older in …

Complement Inhibitors in Age‐Related Macular Degeneration: A Potential Therapeutic Option

S Qin, N Dong, M Yang, J Wang… - Journal of …, 2021 - Wiley Online Library
Age‐related macular degeneration (AMD) is a multifactorial disease, which can culminate in
irreversible vision loss and blindness in elderly. Nowadays, there is a big gap between dry …