The past decade has seen the emergence of immunotherapy as a prime approach to cancer
treatment, revolutionizing the management of many types of cancer. Despite the promise of …

Recent advancements in next-generation sequencing technologies and accompanying
reductions in cost have led to an explosion of techniques to examine DNA accessibility and …

Aging and psychosocial stress are associated with increased inflammation and disease risk,
but the underlying molecular mechanisms are unclear. Because both aging and stress are …

The basis for the endothelial cell-restricted expression of endothelial nitric-oxide synthase
(eNOS) is not known. While transgenic promoter/reporter mice demonstrated endothelium …

Epigenetic modifications play a vital role in the preservation of genome integrity and in the
regulation of gene expression. DNA methylation, one of the key mechanisms of epigenetic …

The role of DNA methylation in the regulation of catabolic genes such as MMP13 and IL1B,
which have sparse CpG islands, is poorly understood in the context of musculoskeletal …

Abstract O6-methylguanine-DNA methyltransferase (MGMT) repairs the cytotoxic and
mutagenic O6-alkylguanine produced by alkylating agents such as chemotherapeutic …

The endometrium undergoes morphological and functional changes during the menstrual
cycle which are essential for uterine receptivity. These changes are driven by estrogen and …

Histone lysine methylation and DNA methylation contribute to transcriptional regulation. We
have previously shown that acetylated histones are associated with unmethylated DNA and …

The DNTM3A and DNMT3B de novo DNA methyltransferases (DNMTs) are responsible for
setting genomic DNA methylation patterns, a key layer of epigenetic information. Here, using …