Chemistry, structure and function of approved oligonucleotide therapeutics
M Egli, M Manoharan - Nucleic Acids Research, 2023 - academic.oup.com
Eighteen nucleic acid therapeutics have been approved for treatment of various diseases in
the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice …
the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice …
CpG DNA as a vaccine adjuvant
C Bode, G Zhao, F Steinhagen, T Kinjo… - Expert review of …, 2011 - Taylor & Francis
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs trigger cells
that express Toll-like receptor 9 (including human plasmacytoid dendritic cells and B cells) …
that express Toll-like receptor 9 (including human plasmacytoid dendritic cells and B cells) …
Immunotherapeutic uses of CpG oligodeoxynucleotides
DM Klinman - Nature Reviews Immunology, 2004 - nature.com
Synthetic oligodeoxynucleotides (ODNs) that contain immunostimulatory CpG motifs trigger
an immunomodulatory cascade that involves B and T cells, natural killer cells and …
an immunomodulatory cascade that involves B and T cells, natural killer cells and …
DNA methylation and memory formation
JJ Day, JD Sweatt - Nature neuroscience, 2010 - nature.com
Memory formation and storage require long-lasting changes in memory-related neuronal
circuits. Recent evidence indicates that DNA methylation may serve as a contributing …
circuits. Recent evidence indicates that DNA methylation may serve as a contributing …
CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.
DM Klinman, AK Yi, SL Beaucage… - Proceedings of the …, 1996 - National Acad Sciences
Bacterial infection stimulates the host to mount a rapid inflammatory response. A 6-base
DNA motif consisting of an unmethylated CpG dinucleotide flanked by two 5'purines and two …
DNA motif consisting of an unmethylated CpG dinucleotide flanked by two 5'purines and two …
DNA vaccines: immunology, application, and optimization
S Gurunathan, DM Klinman… - Annual review of …, 2000 - annualreviews.org
The development and widespread use of vaccines against infectious agents have been a
great triumph of medical science. One reason for the success of currently available vaccines …
great triumph of medical science. One reason for the success of currently available vaccines …
The long and the short of long–term memory—a molecular framework
P Goelet, VF Castellucci, S Schacher, ER Kandel - Nature, 1986 - nature.com
A single learning event initiates several memory processes with different time courses of
retention. While short term memory involves covalent modification of pre-existing proteins …
retention. While short term memory involves covalent modification of pre-existing proteins …
Synthesis and bio-functionalization of magnetic nanoparticles for medical diagnosis and treatment
TD Schladt, K Schneider, H Schild, W Tremel - Dalton Transactions, 2011 - pubs.rsc.org
The synthesis of multifunctional magnetic nanoparticles (NPs) is a highly active area of
current research located at the interface between materials science, biotechnology and …
current research located at the interface between materials science, biotechnology and …
A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA
CpG-DNA or its synthetic analog CpG-ODN activates innate immunity through Toll-like
receptor 9 (TLR9). However, the mechanism of TLR9 activation by CpG-DNA remains …
receptor 9 (TLR9). However, the mechanism of TLR9 activation by CpG-DNA remains …
Sequence specificity of methylation in higher plant DNA
Although plant DNA has a high content of 5-methylcytosine (5mC1) very little is known about
the distribution of this modification. Many of these methylations are found in the dinucleotide …
the distribution of this modification. Many of these methylations are found in the dinucleotide …