Background and Purpose Individualized assessment of cytochrome P450 2D6 (CYP2D6)
activity is usually performed through phenotyping following administration of a probe drug to …

Pharmacokinetics varies widely between children. Many factors play an important role in this
variability, such as ontogeny, pharmacogenetics, gender, comorbidities, and drug-drug …

The suitability of the endogenous 6‐hydroxymelatonin/melatonin urinary metabolic ratio as a
surrogate for the paraxanthine/caffeine ratio to predict cytochrome P450 1A2 (CYP1A2) …

Objectives: Colchicine intoxication is rare but potentially fatal. The toxic dose of colchicine is
not well established; it has been reported that major toxicity starts after doses of 0.5 mg/kg …

Objectives Colchicine intoxication is rare but potentially fatal. The toxic dose of colchicine is
not well established; it has been reported that major toxicity starts after doses of 0.5 mg/kg …

There is extensive interindividual variability in drug response and tolerability. This is to a
major extent caused by differences in the metabolic capacities of the enzymes CYP3A4 and …

The passive targeting of nanocarriers comprises the achievement of their site-specific
delivery based solely on their capacity to exploit physiological and/or pathological …