Current status and perspectives on pharmacologic therapy for abdominal aortic aneurysm
K Yoshimura, N Morikage… - Current drug …, 2018 - ingentaconnect.com
Background: Abdominal aortic aneurysm (AAA), a common disease involving the segmental
expansion and rupture of the aorta, has a high mortality rate. Therapeutic options for AAA …
expansion and rupture of the aorta, has a high mortality rate. Therapeutic options for AAA …
Protocol for the Metformin Aneurysm Trial (MAT): a placebo-controlled randomised trial testing whether metformin reduces the risk of serious complications of …
Background Multiple observational studies have associated metformin prescription with
reduced progression of abdominal aortic aneurysm (AAA). The Metformin Aneurysm Trial …
reduced progression of abdominal aortic aneurysm (AAA). The Metformin Aneurysm Trial …
Pathophysiology of abdominal aortic aneurysm: Biomarkers and novel therapeutic targets
M Torres-Fonseca, M Galan, D Martinez-Lopez… - Clínica e Investigación …, 2019 - Elsevier
Abdominal aortic aneurysm (AAA) is a vascular pathology with a high rate of morbidity and
mortality and a prevalence that, in men over 65 years, can reach around 8%. In this disease …
mortality and a prevalence that, in men over 65 years, can reach around 8%. In this disease …
Research advances in drug therapy for abdominal aortic aneurysms over the past five years: An updated narrative review
R Li, Y Liu, J Jiang - International Journal of Cardiology, 2023 - Elsevier
Background Abdominal aortic aneurysms (AAA) rupture can lead to patient death. Surgical
treatment is currently the optimal treatment for AAA with large diameter (≥ 50 mm). For AAA …
treatment is currently the optimal treatment for AAA with large diameter (≥ 50 mm). For AAA …
Randomized placebo‐controlled trial assessing the effect of 24‐week fenofibrate therapy on circulating markers of abdominal aortic aneurysm: outcomes from the …
JL Pinchbeck, JV Moxon, SE Rowbotham… - Journal of the …, 2018 - Am Heart Assoc
Background There is no drug therapy for abdominal aortic aneurysm (AAA). FAME‐2
(Fenofibrate in the Management of Abdominal Aortic Aneurysm 2) was a placebo‐controlled …
(Fenofibrate in the Management of Abdominal Aortic Aneurysm 2) was a placebo‐controlled …
Molecular pathogenesis of genetic and sporadic aortic aneurysms and dissections
YH Shen, SA LeMaire - Current problems in surgery, 2017 - Elsevier
The aorta is the largest artery and can be divided into several segments (Fig 1). The
diaphragm divides the aorta into the thoracic and abdominal aorta. The thoracic aorta …
diaphragm divides the aorta into the thoracic and abdominal aorta. The thoracic aorta …
Effect of blood pressure lowering drugs and antibiotics on abdominal aortic aneurysm growth: a systematic review and meta-analysis
J Golledge, TP Singh - Heart, 2021 - heart.bmj.com
Objective There is currently no medical treatment proven to limit abdominal aortic aneurysm
(AAA) progression. The aim of this systematic review and meta-analysis was to pool data …
(AAA) progression. The aim of this systematic review and meta-analysis was to pool data …
[HTML][HTML] Targeting metabolism in aortic aneurysm and dissection: from basic research to clinical applications
Q Wang, G Yesitayi, B Liu, D Siti… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Aortic aneurysm and dissection (AAD) are a group of insidious and lethal cardiovascular
diseases that characterized by seriously threatening the life and health of people, but lack …
diseases that characterized by seriously threatening the life and health of people, but lack …
Molecular and cellular mechanisms involved in aortic wall aneurysm development
I Bararu Bojan, CE Pleșoianu, OV Badulescu… - Diagnostics, 2023 - mdpi.com
Aortic aneurysms represent a very common pathology that can affect any segment of the
aorta. These types of aneurysms can be localized on the thoracic segment or on the …
aorta. These types of aneurysms can be localized on the thoracic segment or on the …
Interleukin‐38 suppresses abdominal aortic aneurysm formation in mice by regulating macrophages in an IL1RL2‐p38 pathway‐dependent manner
S Kurose, Y Matsubara, S Yoshino… - Physiological …, 2023 - Wiley Online Library
Macrophages play crucial roles in abdominal aortic aneurysm (AAA) formation through the
inflammatory response and extracellular matrix degradation; therefore, regulating …
inflammatory response and extracellular matrix degradation; therefore, regulating …