Complex biological processes, such as organogenesis and homeostasis, are stringently
regulated by genetic programs that are fine-tuned by epigenetic factors to establish cell fates …

Background Diabetic retinopathy (DR), a specific neuron-vascular complication of diabetes,
is a major cause of vision loss among middle-aged people worldwide, and the number of …

Rod and cone photoreceptors are highly similar in many respects but they have important
functional and molecular differences. Here, we investigate genome-wide patterns of DNA …

Background The growing interest in the role of epigenetic modifications in human health and
disease has led to the development of next-generation sequencing methods for whole …

Polycyclic aromatic hydrocarbons (PAHs) present in crude oil are known to impair visual
development in fish. However, the underlying mechanism of PAH-induced toxicity to the …

DNA hydroxymethylation has recently been shown to play critical roles in regulating gene
expression and terminal differentiation events in a variety of developmental contexts …

Dysfunction or death of photoreceptors is the primary cause of vision loss in retinal and
macular degenerative diseases. As photoreceptors have an intimate relationship with the …

In the developing vertebrate retina, retinal progenitor cells (RPCs) proliferate and give rise to
terminally differentiated neurons with exquisite spatio-temporal precision. Lineage …

Epigenetic regulation of the genome is critical for the emergence of diverse cell lineages
during development. To understand the role of DNA methylation during retinal network …

Defining the number and abundance of different cell types in tissues is important for
understanding disease mechanisms as well as for diagnostic and prognostic purposes …