[HTML][HTML] DNA methylation: an epigenetic mark of cellular memory
M Kim, J Costello - Experimental & molecular medicine, 2017 - nature.com
DNA methylation is a stable epigenetic mark that can be inherited through multiple cell
divisions. During development and cell differentiation, DNA methylation is dynamic, but …
divisions. During development and cell differentiation, DNA methylation is dynamic, but …
DNA methylation: roles in mammalian development
ZD Smith, A Meissner - Nature Reviews Genetics, 2013 - nature.com
DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …
mammalian development. Although the methylation status of most CpG dinucleotides in the …
Stem cells and the impact of ROS signaling
CL Bigarella, R Liang, S Ghaffari - Development, 2014 - journals.biologists.com
An appropriate balance between self-renewal and differentiation is crucial for stem cell
function during both early development and tissue homeostasis throughout life. Recent …
function during both early development and tissue homeostasis throughout life. Recent …
Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
DNA methylation is a key epigenetic modification involved in regulating gene expression
and maintaining genomic integrity. Here we inactivated all three catalytically active DNA …
and maintaining genomic integrity. Here we inactivated all three catalytically active DNA …
Dnmt3a is essential for hematopoietic stem cell differentiation
Loss of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in embryonic stem cells
obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely …
obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely …
[HTML][HTML] DNA methyltransferases: a novel target for prevention and therapy
Cancer is the second leading cause of death in US. Despite the emergence of new, targeted
agents, and the use of various therapeutic combinations, none of the available treatment …
agents, and the use of various therapeutic combinations, none of the available treatment …
[HTML][HTML] Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock
The underlying cause of aging remains one of the central mysteries of biology. Recent
studies in several different systems suggest that not only may the rate of aging be modified …
studies in several different systems suggest that not only may the rate of aging be modified …
[HTML][HTML] Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
HC Tsai, H Li, L Van Neste, Y Cai, C Robert… - Cancer cell, 2012 - cell.com
Reversal of promoter DNA hypermethylation and associated gene silencing is an attractive
cancer therapy approach. The DNA methylation inhibitors decitabine and azacitidine are …
cancer therapy approach. The DNA methylation inhibitors decitabine and azacitidine are …
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
M Ko, HS Bandukwala, J An… - Proceedings of the …, 2011 - National Acad Sciences
The Ten-Eleven-Translocation 2 (TET2) gene encodes a member of TET family enzymes
that alters the epigenetic status of DNA by oxidizing 5-methylcytosine to 5 …
that alters the epigenetic status of DNA by oxidizing 5-methylcytosine to 5 …
Epigenetic control of myeloid cell differentiation, identity and function
Myeloid cells are crucial effectors of the innate immune response and important regulators of
adaptive immunity. The differentiation and activation of myeloid cells requires the timely …
adaptive immunity. The differentiation and activation of myeloid cells requires the timely …