DNA methylation primarily occurs on CpG dinucleotides and plays an important role in
transcriptional regulations during tissue development and cell differentiation. Over 25% of …

Endometriosis is a condition in which cells derived from the endometrium grow outside the
uterus, eg in the peritoneum (external genital endometriosis). As these cells are under the …

Of all biological structures, chromosomes are the most fascinating. They embody the
essence of life, containing the DNA blueprint of evolution and the source of variation in all …

Convincing evidence accumulated over the last decades demonstrates the crucial role of
epigenetic modifications for mammalian genome regulation and its flexibility. DNA …

Pre-eclampsia (PE) is a complication of pregnancy that affects 5‑8% of women after 20
weeks of gestation. It is usually diagnosed based on the de novo onset of hypertension and …

Spinal Muscular Atrophy (SMA) is a neuromuscular disorder caused by mutations in the
SMN1 gene. Being a monogenic disease, it is characterized by high clinical heterogeneity …

Purpose To compare the frequency and the spectrum of karyotype abnormality in the first
trimester miscarriages in women aged under and over 35 years, who conceived naturally …

The presence of an extra chromosome in the embryo karyotype often dramatically affects the
fate of pregnancy. Trisomy 16 is the most common aneuploidy in first-trimester miscarriages …

We performed immunofluorescent analysis of DNA hydroxymethylation and methylation in
human testicular spermatogenic cells from azoospermic patients and ejaculated …

Purpose High frequency of aneuploidy in meiosis and cleavage stage coincides with waves
of epigenetic genome reprogramming that may indicate a possible association between …