Fungal infections are an increasing threat to global public health. There are more than six
million fungal species worldwide, but less than 1% are known to infect humans. Most of …

Cryptococcosis is a systemic fungal infection caused by Cryptococcus neoformans. In
immunocompetent patients, cryptococcal infection is often confined to the lungs. In …

Environmental pathogens move from ecological niches to mammalian hosts, requiring
adaptation to dramatically different environments. Microbes that disseminate farther …

Cryptococcus species are environmental fungal pathogens and the causative agents of
cryptococcosis. Infection occurs upon inhalation of infectious particles, which proliferate in …

The majority of invasive human fungal pathogens gain access to their human hosts via the
inhalation of spores from the environment into the lung, but relatively little is known about …

Vaccines are one of the greatest medical accomplishments to date, yet no fungal vaccines
are currently available in humans mainly because opportunistic mycoses generally occur …

How lung macrophages, especially interstitial macrophages (IMs), respond to invading
pathogens remains elusive. Here, we show that mice exhibited a rapid and substantial …

Cryptococcus neoformans is an opportunistic fungal pathogen and a leading cause of death
in immunocompromised individuals. The interactions of this yeast with host phagocytes are …

Cryptococcal meningitis (CM) is the leading cause of central nervous system (CNS) fungal
infections in humans, with the majority of cases reported from the African continent. This is …

Spliceosomal introns are noncoding sequences that are spliced from pre-mRNA. They are
ubiquitous in eukaryotic genomes, although the average number of introns per gene varies …