Background DNA methylation is likely a key mechanism regulating changes in gene
transcription in traits that show temporal fluctuations in response to environmental …

To identify PBMC-expressed genes significant for RA, and to ascertain their upstream
regulatory factors, as well as downstream functional effects relevant to RA pathogenesis. We …

Abstract Omega-3 or n-3 polyunsaturated fatty acids (PUFAs) are widely studied for health
benefits that may relate to anti-inflammatory activity. However, mechanisms mediating an …

Aim: To identify epigenetically regulated network of genes in peripheral blood mononuclear
cells significant for rheumatoid arthritis (RA). Methods: Differentially expressed genes …

ABSTRACT DNA methylation is highly sensitive to in utero perturbations and has an
established role in both embryonic development and regulation of gene expression. The …

The precise classification of breast cancer subtypes is crucial for clinical diagnosis and
treatment, yet early symptoms are often subtle. The use of multi-omics data from high …

Background To identify RA-associated genes and to ascertain epigenetic factors and
functional mechanisms underlying RA pathogenesis. Methods Peripheral blood …

Although epigenome-wide association studies (EWAS) have been successful in identifying
DNA methylation (DNAm) patterns associated with disease states, any further …

目的· 探讨Fos 相关抗原-2 (Fos-related antigen-2, FRA-2) mRNA 表达水平及DNA
甲基化水平与代谢综合征(metabolic syndrome, MS) 的关系. 方法· 采用病例-对照研究方法 …

In this thesis, I focused on avian seasonal reproduction in times of global warming in the
great tit study population at the Hoge Veluwe. I assessed the evolutionary implications of the …