Epigenetic signatures in gastric cancer: current knowledge and future perspectives

F Sogutlu, M Pekerbas, C Biray Avci - Expert Review of Molecular …, 2022 - Taylor & Francis
Introduction Gastric cancer (GC) is the fifth most common malignancy in the world and
accounts for 7.7% of all cancer-related deaths. Early diagnosis of GC is critical in terms of …

Management of triple-negative breast cancer by natural compounds through different mechanistic pathways

M Kaleem, M Thool, NG Dumore… - Frontiers in …, 2024 - frontiersin.org
Triple-negative breast cancer (TNBC) is the most severe form of breast cancer,
characterized by the loss of estrogen, progesterone, and human epidermal growth factor …

DNMT3B overexpression downregulates genes with CpG islands, common motifs, and transcription factor binding sites that interact with DNMT3B

J Loaeza-Loaeza, AJ Cerecedo-Castillo… - Scientific Reports, 2022 - nature.com
DNA methylation is a key epigenetic modification to regulate gene expression in mammalian
cells. Abnormal DNA methylation in gene promoters is common across human cancer types …

Integrated Analysis of Multiomics Data Identified Molecular Subtypes and Oxidative Stress‐Related Prognostic Biomarkers in Glioblastoma Multiforme

Y Ma, Z Xi - Oxidative Medicine and Cellular Longevity, 2022 - Wiley Online Library
Glioblastoma multiforme (GBM) is a glioma in IV stage, which is one of the most common
primary malignant brain tumors in adults. GBM has the characters of high invasiveness, high …

[HTML][HTML] Methods in DNA methylation array dataset analysis: A review

K Sahoo, V Sundararajan - Computational and Structural Biotechnology …, 2024 - Elsevier
Understanding the intricate relationships between gene expression levels and epigenetic
modifications in a genome is crucial to comprehending the pathogenic mechanisms of many …

Role of HOX genes in cancer progression and their therapeutical aspects

C Yadav, R Yadav, S Nanda, S Ranga, P Ahuja… - Gene, 2024 - Elsevier
HOX genes constitute a family of evolutionarily conserved transcription factors that play
pivotal roles in embryonic development, tissue patterning, and cell differentiation. These …

家蚕DNA 甲基转移酶功能预测及其在BmNPV 感染下的表达特征

张一川, 张永红, 邵榆岚, 白兴荣 - 南方农业学报, 2022 - nfnyxb.xml-journal.net
[目的] 明确家蚕DNA 甲基转移酶基因(BmDNMT) 生物信息学基本特征及其在家蚕核型多角体
病毒(BmNPV) 感染前后的表达情况, 揭示DNA 甲基化在家蚕抗病毒免疫方面的作用机制 …

Epigenetic Regulation of Mammalian Cardiomyocyte Development

IK Mensah, H Gowher - Epigenomes, 2024 - mdpi.com
The heart is the first organ formed during mammalian development and functions to
distribute nutrients and oxygen to other parts of the developing embryo. Cardiomyocytes are …

Dnmt3bas coordinates transcriptional induction and alternative exon inclusion to promote catalytically active Dnmt3b expression

MS Dar, IK Mensah, M He, S McGovern, IS Sohal… - Cell reports, 2023 - cell.com
Embryonic expression of DNMT3B is critical for establishing de novo DNA methylation. This
study uncovers the mechanism through which the promoter-associated long non-coding …

前列腺癌相關之人類基因甲基轉移酶突變體的結構和生化研究

黃薰禾 - 2023 - tdr.lib.ntu.edu.tw
哺乳動物的DNA 甲基化是一種在調節各種細胞事件中, 發揮關鍵作用的表觀遺傳修飾機制.
甲基化失調與多種人類疾病, 包括癌症有關. 在哺乳動物中, DNA 甲基化是由三種DNA …