Lack of genotype‐by‐environment interaction suggests limited potential for evolutionary changes in plasticity in the eastern oyster, Crassostrea virginica

KA Sirovy, KM Johnson, SM Casas… - Molecular …, 2021 - Wiley Online Library
Eastern oysters in the northern Gulf of Mexico are facing rapid environmental changes and
can respond to this change via plasticity or evolution. Plasticity can act as an immediate …

Tumorigenesis: the adaptation of mammalian cells to sustained stress environment by epigenetic alterations and succeeding matched mutations

TV Karpinets, BD Foy - Carcinogenesis, 2005 - academic.oup.com
Recent studies indicate that during tumorigenic transformations, cells may generate
mutations by themselves as a result of error-prone cell division with participation of error …

Pol β gap filling, DNA ligation and substrate-product channeling during base excision repair opposite oxidized 5-methylcytosine modifications

M Çağlayan - DNA repair, 2020 - Elsevier
DNA methylation on cytosine in CpG islands generates 5-methylcytosine (5mC), and further
modification of 5mC can result in the oxidized variants 5-hydroxymethyl (5hmC), 5-formyl …

De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats

IP Pogribny, SJ James - Cancer letters, 2002 - Elsevier
Previous studies have established that chronic dietary insufficiency of the lipotropic nutrients
choline and methionine with or without chemical initiation is hepatocarcinogenic in the rat …

[HTML][HTML] Genomic DNA methylation changes in response to folic acid supplementation in a population-based intervention study among women of reproductive age

KS Crider, EP Quinlivan, RJ Berry, L Hao, Z Li… - PloS one, 2011 - journals.plos.org
Folate is a source of one-carbons necessary for DNA methylation, a critical epigenetic
modification necessary for genomic structure and function. The use of supplemental folic …

[HTML][HTML] Cytogenotoxicity of Cymbopogon citratus (DC) Stapf (lemon grass) aqueous extracts in vegetal test systems

SM Sousa, PS Silva, LF Viccini - Anais da Academia Brasileira de …, 2010 - SciELO Brasil
The lemon grass, Cymbopogon citratus (DC) Stapf, is an important species of Poaceae
family commonly used in the folk medicine in many countries. The aim of this study was to …

High LET 56Fe ion irradiation induces tissue‐specific changes in DNA methylation in the mouse

F Lima, D Ding, W Goetz, AJ Yang… - Environmental and …, 2014 - Wiley Online Library
DNA methylation is an epigenetic mechanism that drives phenotype and that can be altered
by environmental exposures including radiation. The majority of human radiation exposures …

Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old lacZ-transgenic mouse

T Ono, H Ikehata, S Nakamura, Y Saito, Y Hosoi… - Mutation Research …, 2000 - Elsevier
Accumulation of mutation has long been hypothesized to be a cause of aging and contribute
to many of the degenerative diseases, which appear in the senescent phase of life. To test …

Epigenetics: spotlight on type 2 diabetes and obesity

A Desiderio, R Spinelli, M Ciccarelli, C Nigro… - Journal of …, 2016 - Springer
Abstract Type 2 diabetes (T2D) and obesity are the major public health problems.
Substantial efforts have been made to define loci and variants contributing to the individual …

Connexins as precocious markers and molecular targets for chemical and pharmacological agents in carcinogenesis

G Pointis, C Fiorini, J Gilleron, D Carette… - Current medicinal …, 2007 - ingentaconnect.com
Gap junctions, intercellular channels structured by the connexin protein family, have been
implicated in the control of cell homeostasis, proliferation, differentiation and death. A loss of …