The genus Cryptococcus contains two primary species complexes that are significant
opportunistic human fungal pathogens: C. neoformans and C. gattii. In humans …

Macrophages are key cellular components of innate immunity, acting as the first line of
defense against pathogens to modulate homeostatic and inflammatory responses. They …

The polyphenols profiles of the methanol extracts of bitter apricot [Armeniaca Sibirica (L.)]
kernel skins (AKS) were analysed by liquid chromatography-electrospray ionization mass …

The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in
immune compromised individuals. This pathogen is typically acquired via inhalation, and …

Although we have recognized cryptococcosis as a disease entity for well over 100 years,
there are many details about its pathogenesis which remain unknown. A major barrier to …

The human pathogenic fungus Cryptococcus neoformans is a global health concern.
Previous research in the field has focused on studies using reference strains to identify …

Cryptococcal meningoencephalitis caused by Cryptococcus neoformans infection is the
most common cause of death in HIV/AIDS patients. Macrophages are pivotal for the …

The epithelial cell-derived cytokines IL-33 and IL-25 are important mediators in driving type-
2 inflammation during C. neoformans infection. Nevertheless, the impact of these cytokines …

Elevation of arginase enzyme activity in the lung contributes to the pathogenesis of various
chronic inflammatory diseases and infections. Inhibition of arginase expression and activity …

A multifunctional glycoprotein, osteopontin (OPN), can modulate the function of
macrophages, resulting in either protective or deleterious effects in various inflammatory …