The maternal-to-zygotic transition revisited
The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …
Zygotic genome activation during the maternal-to-zygotic transition
MT Lee, AR Bonneau, AJ Giraldez - Annual review of cell and …, 2014 - annualreviews.org
Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development …
animals, maternal factors contributed by the egg cytoplasm initially control development …
Reprogramming the maternal zebrafish genome after fertilization to match the paternal methylation pattern
ME Potok, DA Nix, TJ Parnell, BR Cairns - Cell, 2013 - cell.com
Early vertebrate embryos must achieve totipotency and prepare for zygotic genome
activation (ZGA). To understand this process, we determined the DNA methylation (DNAme) …
activation (ZGA). To understand this process, we determined the DNA methylation (DNAme) …
Active DNA demethylation at enhancers during the vertebrate phylotypic period
O Bogdanović, AH Smits, E de la Calle Mustienes… - Nature …, 2016 - nature.com
The vertebrate body plan and organs are shaped during a conserved embryonic phase
called the phylotypic stage. However, the mechanisms that guide the epigenome through …
called the phylotypic stage. However, the mechanisms that guide the epigenome through …
Evolution of DNA methylome diversity in eukaryotes
Cytosine DNA methylation (5mC) is a widespread base modification in eukaryotic genomes
with critical roles in transcriptional regulation. In recent years, our understanding of 5mC has …
with critical roles in transcriptional regulation. In recent years, our understanding of 5mC has …
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm
DNA methylation plays key roles in diverse biological processes such as X chromosome
inactivation, transposable element repression, genomic imprinting, and tissue-specific gene …
inactivation, transposable element repression, genomic imprinting, and tissue-specific gene …
Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates
Two-thirds of gene promoters in mammals are associated with regions of non-methylated
DNA, called CpG islands (CGIs), which counteract the repressive effects of DNA methylation …
DNA, called CpG islands (CGIs), which counteract the repressive effects of DNA methylation …
Epigenetics in fish gametes and early embryo
The spermatozoa and oocyte are very specialized cells which possess the unique ability to
fuse and to produce an embryo. This embryo will develop into a mature organism capable of …
fuse and to produce an embryo. This embryo will develop into a mature organism capable of …
Chromatin accessibility established by Pou5f3, Sox19b and Nanog primes genes for activity during zebrafish genome activation
In many organisms, early embryonic development is driven by maternally provided factors
until the controlled onset of transcription during zygotic genome activation. The regulation of …
until the controlled onset of transcription during zygotic genome activation. The regulation of …
Zebrafish as a model to study the role of DNA methylation in environmental toxicology
Environmental epigenetics is a rapidly growing field which studies the effects of
environmental factors such as nutrition, stress, and exposure to compounds on epigenetic …
environmental factors such as nutrition, stress, and exposure to compounds on epigenetic …