ABSTRACT DNA methylation is an epigenetic modification critical to normal genome
regulation and development. The vitamin folate is a key source of the one carbon group …

Epigenetics is the study of heritable changes in gene expression that occur without a
change in DNA sequence. Epigenetic phenomena have major economic and medical …

CpG methylation in vertebrates correlates with alterations in chromatin structure and gene
silencing 1, 2, 3, 4. Differences in DNA-methylation status are associated with imprinting …

Fig. 1 Sequence alignments, structures and expression patterns of mouse Dnmt3a and
Dnmt3b. a, Sequences of Dnmt3α and Dnmt3β. Identical amino-acid residues are shaded …

▪ Abstract Choline is an essential nutrient needed for the structural integrity and signaling
functions of cell membranes; for normal cholinergic neurotransmission; for normal muscle …

The present system of radiation protection assumes that exposure at low doses and/or low
dose-rates leads to health risks linearly related to the dose. They are evaluated by a …

DNA methylation, an essential epigenetic feature of DNA that modulates gene expression
and genomic integrity, is catalyzed by methyltransferases that use the universal methyl …

SINCE ITS FIRST recognition in 1948, the fifth base of human DNA, 5-methylcytosine (5-mC)
has generated much interest and considerable controversy during attempts to understand its …

MicroRNAs (miRNAs) are single-stranded RNAs of 18–25 nucleotides that regulate gene
expression at the post-transcriptional level. They are involved in many physiological and …

Exposure to arsenic in contaminated drinking water is an emerging public health problem
that impacts more than 200 million people worldwide. Accumulating lines of evidence from …