Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease
PC Harris, VE Torres - The Journal of clinical investigation, 2014 - Am Soc Clin Investig
Recent advances in defining the genetic mechanisms of disease causation and modification
in autosomal dominant polycystic kidney disease (ADPKD) have helped to explain some …
in autosomal dominant polycystic kidney disease (ADPKD) have helped to explain some …
The role of transient receptor potential cation channels in Ca2+ signaling
M Gees, B Colsoul, B Nilius - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
The 28 mammalian members of the super-family of transient receptor potential (TRP)
channels are cation channels, mostly permeable to both monovalent and divalent cations …
channels are cation channels, mostly permeable to both monovalent and divalent cations …
Monoallelic pathogenic ALG5 variants cause atypical polycystic kidney disease and interstitial fibrosis
Disorders of the autosomal dominant polycystic kidney disease (ADPKD) spectrum are
characterized by the development of kidney cysts and progressive kidney function decline …
characterized by the development of kidney cysts and progressive kidney function decline …
Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations to PKD1 or
PKD2, triggering progressive cystogenesis and typically leading to end-stage renal disease …
PKD2, triggering progressive cystogenesis and typically leading to end-stage renal disease …
Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium
Mutations in the polycystin genes, PKD1 or PKD2, results in Autosomal Dominant Polycystic
Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a …
Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a …
Strategies targeting cAMP signaling in the treatment of polycystic kidney disease
VE Torres, PC Harris - Journal of the American Society of …, 2014 - journals.lww.com
Polycystic kidney disease (PKD) is a leading cause of ESRD worldwide. In PKD, excessive
cell proliferation and fluid secretion, pathogenic interactions of mutated epithelial cells with …
cell proliferation and fluid secretion, pathogenic interactions of mutated epithelial cells with …
Genetics and pathogenesis of polycystic kidney disease
P Igarashi, S Somlo - Journal of the American Society of …, 2002 - journals.lww.com
Polycystic kidney disease (PKD), a common genetic cause of chronic renal failure in
children and adults, is characterized by the accumulation of fluid-filled cysts in the kidney …
children and adults, is characterized by the accumulation of fluid-filled cysts in the kidney …
Metformin improves relevant disease parameters in an autosomal dominant polycystic kidney disease mouse model
NM Pastor-Soler, H Li, J Pham… - American Journal …, 2022 - journals.physiology.org
Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in the
polycystin 1 (PKD1) or polycystin 2 genes, presents with progressive development of kidney …
polycystin 1 (PKD1) or polycystin 2 genes, presents with progressive development of kidney …
[图书][B] Mammalian transient receptor potential (TRP) cation channels
B Nilius, V Flockerzi - 2014 - Springer
When we edited in 2007 the first issue on transient receptor potential channel in the
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …
Genetics, pathobiology and therapeutic opportunities of polycystic liver disease
P Olaizola, PM Rodrigues… - Nature Reviews …, 2022 - nature.com
Polycystic liver diseases (PLDs) are inherited genetic disorders characterized by
progressive development of intrahepatic, fluid-filled biliary cysts (more than ten), which …
progressive development of intrahepatic, fluid-filled biliary cysts (more than ten), which …