In vitro liver cell culture models are gaining increasing importance in pharmacological and
toxicological research. The source of cells used is critical for the relevance and the …

The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …

Clean meat (meat grown in cell culture rather than obtained from animal slaughter) is an
emerging biotechnology industry that will ameliorate the serious environmental …

Background Liver, as a vital organ, is responsible for a wide range of biological functions to
maintain homeostasis and any type of damages to hepatic tissue contributes to disease …

Organoids are in vitro cultures of miniature fetal or adult organ-like structures. Their
potentials for use in tissue and organ replacement, disease modeling, toxicology studies …

Abstract Liver macrophages, Kupffer cells (KCs), play a critical role in drug-induced liver
injury (DILI) and liver diseases including cholestasis, liver fibrosis and viral hepatitis …

Background The advent of human-induced pluripotent stem cells holds great promise for
producing ample individualized hepatocytes. Although previous efforts have succeeded in …

The pharmaceutical industry is in high need of efficient and relevant in vitro liver models,
which can be incorporated in their drug discovery pipelines to identify potential drugs and …

Limited by the poor proliferation and restricted sources of adult hepatocytes, there is an
urgent need to find substitutes for proliferation and cultivation of mature hepatocytes in vitro …

Spinal cord injury (SCI) is a common, severe damage to the central nervous system. Here,
we discuss the use of biomaterials for stem cell transplantation in preclinical and clinical …