Epigenomic maps identify gene regulatory elements by their chromatin state. However,
prevailing short-read sequencing methods cannot effectively distinguish alleles, evaluate …

DNA methylation is the most important epigenetic modification involved in the regulation of
transcription, imprinting, establishment of X-inactivation, and the formation of a chromatin …

Imprinted genes provide an attractive paradigm to unravel links between transcription and
genome architecture. The parental allele-specific expression of these essential genes …

Background There is widespread interest in the three-dimensional chromatin conformation
of the genome and its impact on gene expression. However, these studies frequently do not …

Abstract FKBP5 is a 115‐kb‐long glucocorticoid‐inducible gene implicated in psychiatric
disorders. To investigate the complexities of chromatin interaction frequencies at the FKBP5 …

Dysregulation of the imprinted H19/IGF2 locus can lead to Silver-Russell syndrome (SRS) in
humans. However, the mechanism of how abnormal H19/IGF2 expression contributes to …

Background Adrenal gland is the synthesis and secretion organ of glucocorticoid, which is
crucial to fetal development and postnatal fate. Recently, we found that prenatal …

Parent-of-origin-dependent gene expression of a few hundred human genes is achieved by
differential DNA methylation of both parental alleles. This imprinting is required for normal …

Genomic imprinting plays an important role in the growth and development of mammals.
When the original imprint status of these genes is lost, known as loss of imprinting (LOI), it …

The question of whether behavioral traits are heritable is under debate. An obstacle in
demonstrating transgenerational inheritance in mammals originates from the maternal …