Recommendations for traveling to altitude with neurological disorders

M Falla, G Giardini, C Angelini - Journal of Central Nervous …, 2021 - journals.sagepub.com
Background Several neurological conditions might worsen with the exposure to high altitude
(HA). The aim of this review was to summarize the available knowledge on the neurological …

The oxygen cascade from atmosphere to mitochondria as a tool to understand the (mal) adaptation to hypoxia

M Samaja, S Ottolenghi - International Journal of Molecular Sciences, 2023 - mdpi.com
Hypoxia is a life-threatening challenge for about 1% of the world population, as well as a
contributor to high morbidity and mortality scores in patients affected by various …

Salidroside attenuates high altitude hypobaric hypoxia-induced brain injury in mice via inhibiting NF-κB/NLRP3 pathway

S Jiang, F Fan, L Yang, K Chen, Z Sun, Y Zhang… - European Journal of …, 2022 - Elsevier
Salidroside (Sal), an active ingredient from Rhodiola crenulate, has been reported to exert
neuroprotection in cerebral injury from hypobaric hypoxia (HH) at high altitude. However, it …

Prolonged high-altitude residence impacts verbal working memory: an fMRI study

X Yan, J Zhang, Q Gong, X Weng - Experimental brain research, 2011 - Springer
Oxygen is critical to normal brain functioning and development. In high altitude where the
oxygen concentration and pressure are very low, human cognitive capability such as …

Hypobaric hypoxia modulates brain biogenic amines and disturbs sleep architecture

K Ray, A Dutta, U Panjwani, L Thakur, JP Anand… - Neurochemistry …, 2011 - Elsevier
Sojourners to high altitude experience poor-quality of sleep due to hypobaric hypoxia (HH).
Brain neurotransmitters are the key regulators of sleep wakefulness. Scientific literature has …

Hypoxia causes mitochondrial dysfunction and brain memory disorder in a manner mediated by the reduction of Cirbp

Y Liu, C Xue, H Lu, Y Zhou, R Guan, J Wang… - Science of the Total …, 2022 - Elsevier
Environmental hypoxic hazard has increasingly become a global public health issue, with
impelling evidences supporting the relation between hypoxia and cognitive disorders. As a …

Intermittent hypobaric hypoxic preconditioning provides neuroprotection by increasing antioxidant activity, erythropoietin expression and preventing apoptosis and …

D Coimbra-Costa, F Garzón, N Alva, TCC Pinto… - International Journal of …, 2021 - mdpi.com
Background: Exposure to intermittent hypoxia has been demonstrated to be an efficient tool
for hypoxic preconditioning, preventing damage to cells and demonstrating therapeutic …

Ganoderma lucidum aqueous extract prevents hypobaric hypoxia induced memory deficit by modulating neurotransmission, neuroplasticity and maintaining redox …

P Sharma, R Tulsawani - Scientific Reports, 2020 - nature.com
Oxidative stress due to hypobaric hypoxia at extreme altitudes causes severe neuronal
damage and irreversible cognitive loss. Owing to contraindications of current drug therapies …

Effect of acute, subacute, and repeated exposure to high altitude (5050 m) on psychomotor vigilance

M Pun, SE Hartmann, M Furian, AM Dyck… - Frontiers in …, 2018 - frontiersin.org
Aim: High altitude (HA) hypoxia may affect cognitive performance and sleep quality. Further,
vigilance is reduced following sleep deprivation. We investigated the effect on vigilance …

Hypobaric hypoxia induces depression-like behavior in female Sprague-Dawley rats, but not in males

S Kanekar, OV Bogdanova, PR Olson… - … Altitude Medicine & …, 2015 - liebertpub.com
Abstract Kanekar, Shami, Olena V. Bogdanova, Paul R. Olson, Young-Hoon Sung, Kristen E.
D'Anci, and Perry F. Renshaw. Hypobaric hypoxia induces depression-like behavior in …