DunedinPACE, a DNA methylation biomarker of the pace of aging
Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial
The geroscience hypothesis proposes that therapy to slow or reverse molecular changes
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …
Epigenetic-based age acceleration in a representative sample of older Americans: Associations with aging-related morbidity and mortality
Biomarkers developed from DNA methylation (DNAm) data are of growing interest as
predictors of health outcomes and mortality in older populations. However, it is unknown …
predictors of health outcomes and mortality in older populations. However, it is unknown …
A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking
AT Higgins-Chen, KL Thrush, Y Wang, CJ Minteer… - Nature aging, 2022 - nature.com
Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data,
but this data can be surprisingly unreliable. Here we show that technical noise produces …
but this data can be surprisingly unreliable. Here we show that technical noise produces …
Translational perspective on epigenetics in cardiovascular disease
A plethora of environmental and behavioral factors interact, resulting in changes in gene
expression and providing a basis for the development and progression of cardiovascular …
expression and providing a basis for the development and progression of cardiovascular …
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
S Wahl, A Drong, B Lehne, M Loh, WR Scott, S Kunze… - Nature, 2017 - nature.com
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …
SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions
We report a new class of artifacts in DNA methylation measurements from Illumina
HumanMethylation450 and MethylationEPIC arrays. These artifacts reflect failed …
HumanMethylation450 and MethylationEPIC arrays. These artifacts reflect failed …
Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS
PJ Hop, RAJ Zwamborn, E Hannon… - Science translational …, 2022 - science.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated
heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) …
heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) …
Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control …
JC Chambers, M Loh, B Lehne, A Drong… - The lancet Diabetes & …, 2015 - thelancet.com
Summary Background Indian Asians, who make up a quarter of the world's population, are
at high risk of developing type 2 diabetes. We investigated whether DNA methylation is …
at high risk of developing type 2 diabetes. We investigated whether DNA methylation is …
DNA methylation signatures in peripheral blood strongly predict all-cause mortality
Y Zhang, R Wilson, J Heiss, LP Breitling… - Nature …, 2017 - nature.com
DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we
performed epigenome-wide screening and validation to identify mortality-related DNAm …
performed epigenome-wide screening and validation to identify mortality-related DNAm …