DunedinPACE, a DNA methylation biomarker of the pace of aging

DW Belsky, A Caspi, DL Corcoran, K Sugden… - Elife, 2022 - elifesciences.org
Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial

R Waziry, CP Ryan, DL Corcoran, KM Huffman… - Nature Aging, 2023 - nature.com
The geroscience hypothesis proposes that therapy to slow or reverse molecular changes
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …

Epigenetic-based age acceleration in a representative sample of older Americans: Associations with aging-related morbidity and mortality

JD Faul, JK Kim, ME Levine… - Proceedings of the …, 2023 - National Acad Sciences
Biomarkers developed from DNA methylation (DNAm) data are of growing interest as
predictors of health outcomes and mortality in older populations. However, it is unknown …

A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking

AT Higgins-Chen, KL Thrush, Y Wang, CJ Minteer… - Nature aging, 2022 - nature.com
Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data,
but this data can be surprisingly unreliable. Here we show that technical noise produces …

Translational perspective on epigenetics in cardiovascular disease

P van der Harst, LJ de Windt, JC Chambers - Journal of the American …, 2017 - jacc.org
A plethora of environmental and behavioral factors interact, resulting in changes in gene
expression and providing a basis for the development and progression of cardiovascular …

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

S Wahl, A Drong, B Lehne, M Loh, WR Scott, S Kunze… - Nature, 2017 - nature.com
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …

SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions

W Zhou, TJ Triche Jr, PW Laird… - Nucleic acids research, 2018 - academic.oup.com
We report a new class of artifacts in DNA methylation measurements from Illumina
HumanMethylation450 and MethylationEPIC arrays. These artifacts reflect failed …

Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS

PJ Hop, RAJ Zwamborn, E Hannon… - Science translational …, 2022 - science.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated
heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) …

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control …

JC Chambers, M Loh, B Lehne, A Drong… - The lancet Diabetes & …, 2015 - thelancet.com
Summary Background Indian Asians, who make up a quarter of the world's population, are
at high risk of developing type 2 diabetes. We investigated whether DNA methylation is …

DNA methylation signatures in peripheral blood strongly predict all-cause mortality

Y Zhang, R Wilson, J Heiss, LP Breitling… - Nature …, 2017 - nature.com
DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we
performed epigenome-wide screening and validation to identify mortality-related DNAm …