Cardiovascular diseases (CVDs), such as ischaemic heart disease, cardiomyopathy,
atherosclerosis, hypertension, stroke and heart failure, are among the leading causes of …

Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …

Background: Large-scale human and mechanistic mouse studies indicate a strong
relationship between the microbiome-dependent metabolite trimethylamine N-oxide (TMAO) …

Rationale: Although not fully understood, the phenotypic transition of vascular smooth
muscle cells exhibits at the early onset of the pathology of aortic aneurysms. Exploring the …

The renin-angiotensin (Ang) system (RAS) is a complex hormonal system present locally in
several tissues such as cardiovascular organs. RAS deregulation through overactivation of …

Abdominal aortic aneurysms (AAAs) are highly lethal cardiovascular diseases without
effective medications. However, the molecular and signaling mechanisms remain unclear. A …

The WNT signalling pathway is a key regulator of bone metabolism, particularly bone
formation, which has helped to define the role of osteocytes—the most abundant bone cells …

Abdominal aortic aneurysm (AAA) is a degenerative vascular disease with a complex
aetiology that remains to be fully elucidated. Clinical management of AAA is limited to …

Background Aberrant endoplasmic reticulum stress (ERS) plays an important role in multiple
cardiovascular diseases. However, their implication in intracranial aneurysms (IAs) remains …

Mitochondrial dysfunction has been shown to play a central role in the pathophysiology of
type 2 diabetes (T2D), and mitochondria-targeted agents such as SS-31 are emerging as a …