Transcription, translation and subsequent protein modification represent the transfer of
genetic information from the archival copy of DNA to the short-lived messenger RNA, usually …

The present system of radiation protection assumes that exposure at low doses and/or low
dose-rates leads to health risks linearly related to the dose. They are evaluated by a …

Background DNA methylation in promoters is closely linked to downstream gene repression.
However, whether DNA methylation is a cause or a consequence of gene repression …

Background The regulatory mechanisms underlying tissue specificity are a crucial part of the
development and maintenance of multicellular organisms. A genome-wide analysis of …

Context: Low birth weight (LBW) and unhealthy diets are risk factors of metabolic disease
including type 2 diabetes (T2D). Genetic, nongenetic, and epigenetic data propose a role of …

Background Preeclampsia (PE) is a heterogeneous, hypertensive disorder of pregnancy,
with no robust biomarkers or effective treatments. We hypothesized that this heterogeneity is …

Recent reports suggest that the Tet enzyme family catalytically oxidize 5-methylcytosine in
mammalian cells. The oxidation of 5-methylcytosine can result in three chemically distinct …

Prediction of complex traits using molecular genetic information is an active area in
quantitative genetics research. In the postgenomic era, many types of-omic (eg …

Many imprinted genes are often epigenetically affected in human cancers due to their
functional linkage to insulin and insulin-like growth factor signaling pathways. Thus, the …

Abstract Activator protein 1 (AP-1) is a transcription factor that recognizes two versions of a 7-
base pair response element, either 5΄-T GAG T CA-3΄ or 5΄-M GAG T CA-3΄(where M= 5 …