Rett syndrome: a complex disorder with simple roots
MJ Lyst, A Bird - Nature Reviews Genetics, 2015 - nature.com
Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the X-linked
gene MECP2 (methyl-CpG-binding protein 2). Two decades of research have fostered the …
gene MECP2 (methyl-CpG-binding protein 2). Two decades of research have fostered the …
[HTML][HTML] The molecular basis of MeCP2 function in the brain
R Tillotson, A Bird - Journal of molecular biology, 2020 - Elsevier
MeCP2 is a reader of the DNA methylome that occupies a large proportion of the genome
due to its high abundance and the frequency of its target sites. It has been the subject of …
due to its high abundance and the frequency of its target sites. It has been the subject of …
MeCP2 links heterochromatin condensates and neurodevelopmental disease
Abstract Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive
heterochromatin, which is crucial for chromosome maintenance and transcriptional …
heterochromatin, which is crucial for chromosome maintenance and transcriptional …
Rett syndrome-causing mutations compromise MeCP2-mediated liquid–liquid phase separation of chromatin
Rett syndrome (RTT), a severe postnatal neurodevelopmental disorder, is caused by
mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2). MeCP2 is …
mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2). MeCP2 is …
Rett syndrome and MeCP2
VRB Liyanage, M Rastegar - Neuromolecular medicine, 2014 - Springer
Rett syndrome (RTT) is a severe and progressive neurological disorder, which mainly affects
young females. Mutations of the methyl-CpG binding protein 2 (MECP2) gene are the most …
young females. Mutations of the methyl-CpG binding protein 2 (MECP2) gene are the most …
Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome
BS Johnson, YT Zhao, M Fasolino, JM Lamonica… - Nature medicine, 2017 - nature.com
Mutations in MECP2 cause Rett syndrome (RTT), an X-linked neurological disorder
characterized by regressive loss of neurodevelopmental milestones and acquired …
characterized by regressive loss of neurodevelopmental milestones and acquired …
The molecular basis of variable phenotypic severity among common missense mutations causing Rett syndrome
K Brown, J Selfridge, S Lagger… - Human molecular …, 2016 - academic.oup.com
Rett syndrome is caused by mutations in the X-linked MECP2 gene, which encodes a
chromosomal protein that binds to methylated DNA. Mouse models mirror the human …
chromosomal protein that binds to methylated DNA. Mouse models mirror the human …
MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites
RP Ghosh, RA Horowitz-Scherer… - … and cellular biology, 2010 - Am Soc Microbiol
Sporadic mutations in the hMeCP2 gene, coding for a protein that preferentially binds
symmetrically methylated CpGs, result in the severe neurological disorder Rett syndrome …
symmetrically methylated CpGs, result in the severe neurological disorder Rett syndrome …
[HTML][HTML] The cell biology of DNA methylation in mammals
E Prokhortchouk, PA Defossez - … et Biophysica Acta (BBA)-Molecular Cell …, 2008 - Elsevier
In this review, we will provide a brief reminder of epigenetic phenomena in general, and
DNA methylation in particular. We will then underline the characteristics of the in vivo …
DNA methylation in particular. We will then underline the characteristics of the in vivo …
A temporal threshold for formaldehyde crosslinking and fixation
Background Formaldehyde crosslinking is in widespread use as a biological fixative for
microscopy and molecular biology. An assumption behind its use is that most biologically …
microscopy and molecular biology. An assumption behind its use is that most biologically …