Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the X-linked
gene MECP2 (methyl-CpG-binding protein 2). Two decades of research have fostered the …

MeCP2 is a reader of the DNA methylome that occupies a large proportion of the genome
due to its high abundance and the frequency of its target sites. It has been the subject of …

Abstract Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive
heterochromatin, which is crucial for chromosome maintenance and transcriptional …

Rett syndrome (RTT), a severe postnatal neurodevelopmental disorder, is caused by
mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2). MeCP2 is …

Rett syndrome (RTT) is a severe and progressive neurological disorder, which mainly affects
young females. Mutations of the methyl-CpG binding protein 2 (MECP2) gene are the most …

Mutations in MECP2 cause Rett syndrome (RTT), an X-linked neurological disorder
characterized by regressive loss of neurodevelopmental milestones and acquired …

Rett syndrome is caused by mutations in the X-linked MECP2 gene, which encodes a
chromosomal protein that binds to methylated DNA. Mouse models mirror the human …

Sporadic mutations in the hMeCP2 gene, coding for a protein that preferentially binds
symmetrically methylated CpGs, result in the severe neurological disorder Rett syndrome …

In this review, we will provide a brief reminder of epigenetic phenomena in general, and
DNA methylation in particular. We will then underline the characteristics of the in vivo …

Background Formaldehyde crosslinking is in widespread use as a biological fixative for
microscopy and molecular biology. An assumption behind its use is that most biologically …