The anaphylatoxin C5a: Structure, function, signaling, physiology, disease, and therapeutics
The complement system is one of the oldest known tightly regulated host defense systems
evolved for efficiently functioning cell-based immune systems and antibodies. Essentially …
evolved for efficiently functioning cell-based immune systems and antibodies. Essentially …
Understanding the contextual functions of C1q and LAIR-1 and their applications
M Son - Experimental & Molecular Medicine, 2022 - nature.com
The importance of the complement component C1q has been highlighted by its involvement
in autoimmunity, infection, inflammatory diseases, and tumors. The unique tulip-like structure …
in autoimmunity, infection, inflammatory diseases, and tumors. The unique tulip-like structure …
Single‐cell RNAseq provides insight into altered immune cell populations in human fracture nonunions
KG Avin, JM Dominguez 2nd, NX Chen… - Journal of …, 2023 - Wiley Online Library
Nonunion describes bone fractures that fail to heal, resulting in the fracture callus failing to
fully ossify or, in atrophic cases, not forming altogether. Fracture healing is regulated, in part …
fully ossify or, in atrophic cases, not forming altogether. Fracture healing is regulated, in part …
The pathogenesis and potential therapeutic targets in sepsis
W Zhang, H Jiang, G Wu, P Huang, H Wang, H An… - MedComm, 2023 - Wiley Online Library
Sepsis is defined as “a life‐threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection.” At present, sepsis continues to …
systemic inflammatory and immune response to infection.” At present, sepsis continues to …
[HTML][HTML] The inflammatory response is related to circulatory failure after out-of-hospital cardiac arrest: A prospective cohort study
H Langeland, JK Damås, TE Mollnes, JK Ludviksen… - Resuscitation, 2022 - Elsevier
Background Whole body ischemia and reperfusion injury after cardiac arrest leads to the
massive inflammation clinically manifested in the post-cardiac arrest syndrome. Previous …
massive inflammation clinically manifested in the post-cardiac arrest syndrome. Previous …
Double‐network hydrogel armored decellularized porcine pericardium as durable bioprosthetic heart valves
S Cheng, X Liu, Y Qian, M Maitusong… - Advanced …, 2022 - Wiley Online Library
Heart valves have extraordinary fatigue resistance which beat≈ 3 billion times in a lifetime.
Bioprosthetic heart valves (BHVs) made from fixed heteroplasm that are incrementally used …
Bioprosthetic heart valves (BHVs) made from fixed heteroplasm that are incrementally used …
Targeting complement in neurodegeneration: challenges, risks, and strategies
WM Zelek, BP Morgan - Trends in Pharmacological Sciences, 2022 - cell.com
Evidence implicating complement in neuroinflammatory and neurodegenerative diseases
(NDDs) has accumulated over the past decade, revealing complement as a driver of …
(NDDs) has accumulated over the past decade, revealing complement as a driver of …
Expanding horizons in complement analysis and quality control
A Frazer-Abel, M Kirschfink, Z Prohászka - Frontiers in immunology, 2021 - frontiersin.org
Complement not only plays a key role in host microbial defense but also modulates the
adaptive immune response through modification of T-and B-cell reactivity. Moreover, a …
adaptive immune response through modification of T-and B-cell reactivity. Moreover, a …
Simultaneous C5 and CD14 inhibition limits inflammation and organ dysfunction in pig polytrauma
L Lupu, K Horst, J Greven, Ü Mert… - Frontiers in …, 2022 - frontiersin.org
Dysfunctional complement activation and Toll-like receptor signaling immediately after
trauma are associated with development of trauma-induced coagulopathy and multiple …
trauma are associated with development of trauma-induced coagulopathy and multiple …
Interaction between the complement system and infectious agents–a potential mechanistic link to neurodegeneration and dementia
As part of the innate immune system, complement plays a critical role in the elimination of
pathogens and mobilization of cellular immune responses. In the central nervous system …
pathogens and mobilization of cellular immune responses. In the central nervous system …