EACTS/STS Guidelines for diagnosing and treating acute and chronic syndromes of the aortic organ

M Czerny, M Grabenwöger, T Berger… - European Journal of …, 2024 - academic.oup.com
These guidelines, endorsed by both the EACTS and STS, represent the official viewpoint on
this topic. They show a commitment to ongoing improvement, as regular updates will be …

The perspective of cAMP/cGMP signaling and cyclic nucleotide phosphodiesterases in aortic aneurysm and dissection

T Shu, Y Zhou, C Yan - Vascular Pharmacology, 2024 - Elsevier
Aortic aneurysm (AA) and dissection (AD) are aortic diseases caused primarily by medial
layer degeneration and perivascular inflammation. They are lethal when the rupture …

The aortic paradox: a nationwide analysis of 523,994 individual echocardiograms exploring fatal aortic dissection

ED Paratz, J Nadel, J Humphries… - European Heart …, 2024 - academic.oup.com
Background Increasing aortic dilation increases the risk of aortic dissection. Nevertheless,
dissection occurs at dimensions below guideline-directed cut-offs for prophylactic surgery …

[HTML][HTML] Enhanced Expression of miR-20a Driven by Nanog Exacerbated the Degradation of Extracellular Matrix in Thoracic Aortic Dissection

Z An, Y Sun, X Yang, J Zhou, Y Yu, B Zhang… - Non-coding RNA …, 2024 - Elsevier
Thoracic aortic dissection (TAD) is a life-threatening vascular disease manifested as
intramural bleeding in the medial layers of the thoracic aorta. The key histopathologic …

[HTML][HTML] Understanding genomic medicine for thoracic aortic disease through the lens of induced pluripotent stem cells

AA Singh, DK Shetty, AG Jacob, S Bayraktar… - Frontiers in …, 2024 - frontiersin.org
Thoracic aortic disease (TAD) is often silent until a life-threatening complication occurs.
However, genetic information can inform both identification and treatment at an early stage …

[HTML][HTML] Uncovering Druggable Targets in Aortic Dissection: An Association Study Integrating Mendelian Randomization, pQTL, and Protein–Protein Interaction …

D Jiang, S Zheng, X Xu, H Yue, W Liang, Z Wu - Biomedicines, 2024 - mdpi.com
Aortic dissection (AD) is a life-threatening acute aortic syndrome. There are limitations and
challenges in the discovery and application of biomarkers and drug targets for AD …

[HTML][HTML] Factors Associated with Early Mortality in Acute Type A Aortic Dissection—A Single-Centre Experience

P Doukas, N Dalibor, A Keszei, J Frankort… - Journal of Clinical …, 2024 - mdpi.com
Background: Acute aortic dissection type A (AADA) is a surgical emergency with relevant
mortality and morbidity despite improvements in current management protocols. Identifying …

Epidemiology of Acute Aortic Dissection in a General Population of 1.4 Million People in Japan―Shiga Stroke and Heart Attack Registry―

Y Higo, Y Sawayama, N Takashima, A Harada… - Circulation …, 2023 - jstage.jst.go.jp
Background: Acute aortic dissection (AAD) is a life-threatening cardiovascular disease, with
a reported incidence rate ranging from 2.5 to 7.2 per 100,000 person-years in several …

Sacubitril/valsartan as an effective hypertension treatment option in those with chronic type B aortic dissection

MG Buhnerkempe, S Bitner… - American Journal of …, 2024 - academic.oup.com
Aortic dissection (AD) impacts around 4.8 per 100,000 individuals per year1. Intimal tears in
the descending aorta, Stanford type B aortic dissections (TBAD), account for 25–40% of …

Atherosclerotic Calcifications Have a Local Effect on the Peel Behavior of Human Aortic Media

CL Donahue, RM Badal… - Journal of …, 2024 - asmedigitalcollection.asme.org
Aortic dissections, characterized by the propagation of a tear through the layers of the vessel
wall, are critical, life-threatening events. Aortic calcifications are a common comorbidity in …