DNA methylation QTL mapping across diverse human tissues provides molecular links between genetic variation and complex traits
M Oliva, K Demanelis, Y Lu, M Chernoff, F Jasmine… - Nature …, 2023 - nature.com
Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-
specific characterization of DNAm is needed to understand its role in gene regulation and its …
specific characterization of DNAm is needed to understand its role in gene regulation and its …
The molecular pathology of schizophrenia: An overview of existing knowledge and new directions for future research
T Nakamura, A Takata - Molecular Psychiatry, 2023 - nature.com
Despite enormous efforts employing various approaches, the molecular pathology in the
schizophrenia brain remains elusive. On the other hand, the knowledge of the association …
schizophrenia brain remains elusive. On the other hand, the knowledge of the association …
Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders
There is growing evidence for the role of DNA methylation (DNAm) quantitative trait loci
(mQTLs) in the genetics of complex traits, including psychiatric disorders. However, due to …
(mQTLs) in the genetics of complex traits, including psychiatric disorders. However, due to …
CRISPR/Cas-based approaches to study schizophrenia and other neurodevelopmental disorders
AO Kurishev, DS Karpov, NI Nadolinskaia… - International Journal of …, 2022 - mdpi.com
The study of diseases of the central nervous system (CNS) at the molecular level is
challenging because of the complexity of neural circuits and the huge number of specialized …
challenging because of the complexity of neural circuits and the huge number of specialized …
Oct4A palmitoylation modulates tumorigenicity and stemness in human glioblastoma cells
X Chen, W Niu, X Fan, H Yang, C Zhao, J Fan… - Neuro …, 2023 - academic.oup.com
Background Glioblastoma multiforme and other solid malignancies are heterogeneous,
containing subpopulations of tumor cells that exhibit stem characteristics. Oct4, also known …
containing subpopulations of tumor cells that exhibit stem characteristics. Oct4, also known …
Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry
KJM Benjamin, Q Chen, NJ Eagles… - Nature …, 2024 - nature.com
Ancestral differences in genomic variation affect the regulation of gene expression; however,
most gene expression studies have been limited to European ancestry samples or adjusted …
most gene expression studies have been limited to European ancestry samples or adjusted …
Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA methylation and …
BC McKinney, LL McClain, CM Hensler, Y Wei… - Translational …, 2022 - nature.com
DNA methylation (DNAm), the addition of a methyl group to a cytosine in DNA, plays an
important role in the regulation of gene expression. Single-nucleotide polymorphisms …
important role in the regulation of gene expression. Single-nucleotide polymorphisms …
Genetic risk of osteoarthritis operates during human skeletogenesis
SJ Rice, A Brumwell, J Falk… - Human Molecular …, 2023 - academic.oup.com
Osteoarthritis (OA) is a polygenic disease of older people resulting in the breakdown of
cartilage within articular joints. Although it is a leading cause of disability, there are no …
cartilage within articular joints. Although it is a leading cause of disability, there are no …
CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder
ST Nagamatsu, G Rompala, YL Hurd… - Frontiers in …, 2023 - frontiersin.org
Introduction DNA methylation (DNAm), an epigenetic mechanism, has been associated with
opioid use disorder (OUD) in preclinical and human studies. However, most of the studies …
opioid use disorder (OUD) in preclinical and human studies. However, most of the studies …
Molecular phenotypes associated with antipsychotic drugs in the human caudate nucleus
KA Perzel Mandell, NJ Eagles, A Deep-Soboslay… - Molecular …, 2022 - nature.com
Antipsychotic drugs are the current first-line of treatment for schizophrenia and other
psychotic conditions. However, their molecular effects on the human brain are poorly …
psychotic conditions. However, their molecular effects on the human brain are poorly …