One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

Metformin is the first-line treatment for many people with type 2 diabetes mellitus (T2DM)
and gestational diabetes mellitus (GDM) to maintain glycaemic control. Recent evidence …

Complex molecular mechanisms define our responses to environmental stimuli. Beyond the
DNA sequence itself, epigenetic machinery orchestrates changes in gene expression …

Insulin resistance (IR) is largely recognized as a unifying feature that underlies metabolic
dysfunction. Both lifestyle and genetic factors contribute to IR. Work from recent years has …

Nutrition and metabolism modify epigenetic signatures like histone acetylation and DNA
methylation. Histone acetylation and DNA methylation in the central nervous system (CNS) …

Background Gestational diabetes mellitus (GDM), characterized by hyperglycemia that
develops during pregnancy, increases the risk of fetal macrosomia, childhood obesity and …

Objective: The aim of this study was to evaluate maternal serum levels of folate, vitamin B12
and their ratio on admission for labour and determine whether an imbalance between folate …

Patients with chronic kidney disease or end-stage renal disease experience tremendous
cardiovascular risk. Cardiovascular events are the leading causes of death in these patient …

Despite the advances in treatment using chemotherapy or targeted therapies, due to static
survival rates, non-small cell lung cancer (NSCLC) is the major cause of cancer-related …

Simple Summary Ulcerative colitis, a form of inflammatory bowel disease, is a major risk
factor for developing colorectal cancer. Patients with ulcerative colitis often present with low …