Similar to other mammalian viruses, the life cycle of hepatitis B virus (HBV) is heavily
dependent upon and regulated by cellular (host) functions. These cellular functions can be …

Hepatitis B virus (HBV), the well-studied oncovirus that contributes to the majority of
hepatocellular carcinomas (HCC) worldwide, can cause a severe inflammatory …

The pathogenesis of hepatocellular carcinoma (HCC) is a multistep process, involving the
progressive accumulation of molecular alterations and transcriptomic alterations. The …

Hepatitis B virus (HBV) is a major human pathogen lacking a reliable curative therapy.
Current therapeutics target the viral reverse transcriptase/DNA polymerase to inhibit viral …

The present study determined the expression and biological functions of FOXA2 gene in
colon cancer in tissues, cells and animals. A total of 66 patients with colon cancer were …

The prolonged viral antigen stimulation is the driving force for the development of immune
tolerance to chronic hepatitis B virus (HBV) infection. The sustained reduction of viral …

Abstract Background Hepatitis B virus (HBV) is a leading cause of liver failure and
hepatocellular carcinoma. Approximately 10% of people with HIV also have HBV and are at …

Many infectious diseases in humans present with a sex bias. This bias arises from a
combination of environmental factors, hormones and genetics. In this study, we review the …

Liver-specific ten-eleven translocation (Tet) methylcytosine dioxygenases 2 and 3 (Tet2 plus
Tet3)-deficient hepatitis B virus (HBV) transgenic mice fail to support viral biosynthesis. The …

Abstract Forkhead box A2 (FOXA2) has emerged as a tumor inhibitor in several human
malignancies. This work focused on the effect of FOXA2 on liver cancer (LC) cell invasion …