A mounting body of research points to cerebrovascular dysfunction as a fundamental
element in the pathophysiology of Parkinson's disease (PD). In the current feasibility study …

Alteration in brain metabolism predates clinical onset of Alzheimer's Disease (AD). Realizing
its potential as an early diagnostic marker, however, requires understanding how early AD …

Timely reperfusion of ischemic tissues and hemodynamic reconstruction is key to the
treatment of acute ischemic stroke (AIS). The low temporal resolution of current imaging …

Cerebrovascular reactivity (CVR) is a dynamic measure of the cerebral blood vessel
response to vasoactive stimulus. Conventional CVR measures amplitude changes in the …

Aging is accompanied by vascular and structural changes in the brain, which include
decreased grey matter volume (GMV), cerebral blood flow (CBF), and cerebrovascular …

Cerebral small vessel disease (cSVD) encompasses a heterogeneous group of age-related
small vessel pathologies that affect multiple regions. Disease manifestations range from …

The preservation of cognitive function in old age is a public health priority. Cerebral
hypoperfusion is a hallmark of dementia but its impact on maintaining cognitive ability …

Cerebral autoregulation is an intrinsic myogenic response of cerebral vasculature that
allows for preservation of stable cerebral blood flow levels in response to changing systemic …

Functional near infrared spectroscopy (fNIRS) measurements are confounded by signal
components originating from multiple physiological causes, whose activities may vary …

Elevated carbon dioxide (CO2) in breathing air is widely used as a vasoactive stimulus to
assess cerebrovascular functions under hypercapnia (ie,“stress test” for the brain). Blood …