Autosomal dominant polycystic kidney disease is the most common inherited kidney disease
and accounts for 7–10% of all patients on renal replacement therapy worldwide. Although …

Polycystin subunits can form hetero-and homotetrameric ion channels in the membranes of
various compartments of the cell. Homotetrameric polycystin channels are voltage-and …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive
cyst formation that ultimately leads to kidney failure in most patients. Approximately 10% of …

The initial breaking of left-right (L–R) symmetry in the embryo is controlled by a motile-cilia-
driven leftward fluid flow in the left-right organiser (LRO), resulting in L–R asymmetric gene …

Polycystic kidney disease (PKD) is a multiorgan disorder resulting in fluid-filled cyst
formation in the kidneys and other systems. The replacement of kidney parenchyma with an …

The Hippo pathway nuclear effector Yes-associated protein (YAP) potentiates the
progression of polycystic kidney disease (PKD) arising from ciliopathies. The mechanisms …

The alteration of water balance and related disorders has emerged as being strictly linked to
the state of activation of the vasopressin–aquaporin-2 (vasopressin–AQP2) pathway. The …

Heterogeneity of lymphatic vessels during embryogenesis is critical for organ-specific
lymphatic function. Little is known about lymphatics in the developing kidney, despite their …

The prevalence of chronic kidney disease (CKD) is rapidly increasing over the last few
decades, owing to the global increase in diabetes and cardiovascular diseases. Dialysis …

The major hallmark of Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the
formation of many fluid-filled cysts in the kidneys, which ultimately impairs the normal renal …