CCDC (coiled-coil domain-containing) is a coiled helix domain that exists in natural proteins.
There are about 180 CCDC family genes, encoding proteins that are involved in intercellular …

Neuroblastoma (NB) is a pediatric cancer of the sympathetic nervous system and one of the
most common solid tumors in infancy. Amplification of MYCN, copy number alterations …

Neuroblastoma is the most common solid tumor in children under the age of one. It displays
remarkable phenotypic heterogeneity, resulting in differences in outcomes that correlate with …

Pediatric solid tumors have long been known to shed tumor cells, DNA, RNA, and proteins
into the blood. Recent technological advances have allowed for improved capture and …

Head and neck squamous cell carcinoma (HNSCC), a highly heterogeneous disease that
involves multiple anatomic sites, is a leading cause of cancer‐related mortality worldwide …

In recent years, technological advances have enabled a detailed landscaping of the
epigenome and the mechanisms of epigenetic regulation that drive normal cell function …

Next-generation sequencing and bioinformatics analyses have clearly revealed the roles of
mitochondrial ribosomal genes in cancer development. Mitochondrial ribosomes are …

As our understanding of neuroblastoma biology deepens, our approaches to therapy for this
disease continue to evolve. Improved risk stratification and the use of predictive biomarkers …

Precision-based molecular phenotyping of heart failure must overcome limited access to
cardiac tissue. Although epigenetic alterations have been found to underlie pathological …

Pediatric cancers rarely exhibit recurrent mutational events when compared to most adult
cancers. This poses a challenge in understanding how cancers initiate, progress, and …