The brain is the central organ of stress and adaptation to stress because it perceives and
determines what is threatening, as well as the behavioral and physiological responses to the …

The initiation and progression of cancer is controlled by both genetic and epigenetic events.
Unlike genetic alterations, which are almost impossible to reverse, epigenetic aberrations …

Covalent modification of histones has an important role in regulating chromatin dynamics
and transcription. Whereas most covalent histone modifications are reversible, until recently …

To better understand the molecular mechanisms of depression and antidepressant action,
we administered chronic social defeat stress followed by chronic imipramine (a tricyclic …

Epigenetic marking systems confer stability of gene expression during mammalian
development. Genome-wide epigenetic reprogramming occurs at stages when …

It is more evident now than ever that nucleosomes can transmit epigenetic information from
one cell generation to the next. It has been demonstrated during the past decade that the …

Covalent modification of histones plays an important role in regulating chromatin dynamics
and transcription. Histone methylation was thought to be an irreversible modification until …

Methylation of histones modulates chromatin structure and function. Whereas methylation of
histone H3 on lysines 4, 36, and 79 has been linked with gene activation, methylation of H3 …

Methylation of lysine and arginine residues on histone tails affects chromatin structure and
gene transcription,,. Tri-and dimethylation of lysine 9 on histone H3 (H3K9me3/me2) is …

Recent studies demonstrated that histone methylation is not static but is dynamically
regulated by histone methyltransferases and the newly discovered histone demethylases …