Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin,
phenotypic and functional heterogeneity, are the most essential components of the tumor …

To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

Most (if not all) tumors emerge and progress under a strong evolutionary pressure imposed
by trophic, metabolic, immunological, and therapeutic factors. The relative impact of these …

As a point of convergence for numerous oncogenic signaling pathways, signal transducer
and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune …

Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …

In chronic infection, inflammation and cancer, the tissue microenvironment controls how
local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in …

Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …

Among all the stromal cells that present in the tumor microenvironment, cancer-associated
fibroblasts (CAFs) are one of the most abundant and critical components of the tumor …

Current paradigms of cancer-centric therapeutics are usually not sufficient to eradicate the
malignancy, as the cancer stroma may prompt tumour relapse and therapeutic resistance …

Pancreatic ductal adenocarcinoma (PDAC) is poorly responsive to therapies and
histologically contains a paucity of neoplastic cells embedded within a dense desmoplastic …