Vitamin B12 plays a key role in DNA stability. Research indicates that vitamin B12 deficiency
leads to indirect DNA damage, and vitamin B12 supplementation may reverse this effect …

Although targeted therapy and immunotherapy greatly improve the outcome of melanoma,
drug resistance and low response rates still maintain the unsubstitutability of traditional …

Human flap endonuclease 1 (hFEN1) is instrumental in DNA replication and repair. It is able
to cleave the 5′ single-stranded protrusion (also known as 5′ flap) resulting from strand …

Paclitaxel (taxol) is one of the most powerful anticancer drugs but it possesses toxic effects
on male reproductive system. Propolis, from folkloric remedy, have antioxidant, anti …

Since DNA damage can occur spontaneously or be produced by the environmental
genotoxins in living cells, it is important to investigate compounds that can reverse or protect …

Cisplatin is an anticancer drug that is widely used in treatments of human malignancies such
as ovaries,'testes,'and solid tumors of the head and neck. However, the use of cisplatin in the …

Studies on cervical cancer are urgently required to improve clinical outcomes. As a major
anticancer drug for cervical cancer, paclitaxel has been used for many years in clinical …

Sperm cryopreservation may lead to adverse effects on sperm structure and function.
Cyanocobalamin (vitamin B12) has antioxidant potential and can protect DNA from free …

ABSTRACT Vincristine (VCR), vinblastine (VBL) and vinorelbine (VRL) are anticancer
agents from the Vinca alkaloid family that have the potential to induce genotoxic effect. The …

Semen cryopreservation is an important technique for preserving the genetic material of
numerous species. However, frozen semen is highly susceptible to sperm DNA damage and …