Metals are essential for life, and they play a central role in the struggle between infecting
microbes and their hosts. In fact, an important aspect of microbial pathogenesis is the …

Iron is the most abundant transition metal in the human body and its bioavailability is
stringently controlled. In particular, iron is tightly bound to host proteins such as transferrin to …

Iron is required by most living systems. A great variety of means of acquisition, avenues of
uptake, and methods of storage are used by pathogenic fungi to ensure a supply of the …

The devastating infections that fungal pathogens cause in humans are underappreciated
relative to viral, bacterial and parasitic diseases. In recent years, the contributions to …

Aspergillus fumigatus is the leading cause of invasive mold infection and is a serious
problem in immunocompromised populations worldwide. We have previously shown that …

Cryptococcus gattii recently emerged as the causative agent of cryptococcosis in healthy
individuals in western North America, despite previous characterization of the fungus as a …

Iron overload is known to exacerbate many infectious diseases, and conversely, iron
withholding is an important defense strategy for mammalian hosts. Iron is a critical cue for …

Fungal pathogens must assimilate local nutrients to establish an infection in their
mammalian host. We focus on carbon, nitrogen, and micronutrient assimilation mechanisms …

The fungal pathogen Cryptococcus neoformans is a major cause of illness in
immunocompromised individuals such as AIDS patients. The ability of the fungus to acquire …

The level of available iron in the mammalian host is extremely low, and pathogenic microbes
must compete with host proteins such as transferrin for iron. Iron regulation of gene …