Pioneer factors are transcription factors with the unique ability to initiate opening of closed
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …

Maintenance of genome stability requires control over the expression of transposable
elements (TEs), whose activity can have substantial deleterious effects on the host …

DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …

Human in vitro gametogenesis may transform reproductive medicine. Human pluripotent
stem cells (hPSCs) have been induced into primordial germ cell–like cells (hPGCLCs); …

Ancestral environmental exposures to a variety of factors and toxicants have been shown to
promote the epigenetic transgenerational inheritance of adult onset disease. One of the …

Much attention has focussed on the conversion of human pluripotent stem cells (PSCs) to a
more naïve developmental status. Here we provide a method for resetting via transient …

Cross-species comparisons of genomes, transcriptomes and gene regulation are now
feasible at unprecedented resolution and throughput, enabling the comparison of human …

Human pluripotent stem cells (hPSCs) are of fundamental relevance in regenerative
medicine. Naïve hPSCs hold promise to overcome some of the limitations of conventional …

DNA methylation (DNAme) is an important epigenetic mark in diverse species. Our current
understanding of DNAme is based on measurements from bulk cell samples, which …

Mammalian male germ cell development is a stepwise cell-fate transition process; however,
the full-term developmental profile of male germ cells remains undefined. Here, by …