Lithium has been used for over half a century for the treatment of bipolar disorder as the
archetypal mood stabilizer, and has a wealth of empirical evidence supporting its efficacy in …

Major psychiatric illnesses such as mood disorders and schizophrenia are chronic, recurrent
mental illnesses that affect the lives of millions of individuals. Although these disorders have …

Background Migraine is a highly prevalent and disabling neurological disorder which is
commonly linked with a broad range of psychiatric comorbidities, especially among subjects …

Athletes, body builders, and military personnel use dietary creatine as an ergogenic aid to
boost physical performance in sports involving short bursts of high-intensity muscle activity …

Biological studies of bipolar disorder initially focused on the mechanism of action for
antidepressants and antipsychotic drugs, and the roles of monoamines (eg, serotonin …

Gigante AD, Bond DJ, Lafer B, Lam RW, Young LT, Yatham LN. Brain glutamate levels
measured by magnetic resonance spectroscopy in patients with bipolar disorder: a meta …

Previously, we found decreased mitochondrial complex I subunits levels and increased
protein oxidation and nitration in postmortem prefrontal cortex (PFC) from patients with …

Genome-wide association studies (GWAS) have reported substantial genomic loci
significantly associated with clinical risk of bipolar disorder (BD), and studies combining …

Although evidence for mitochondrial dysfunction in the pathogenesis of bipolar disorder
(BD) has been reported, the precise biological basis remains unknown, hampering the …

We report the first genome-wide association study in 1000 bipolar I patients and 1000
controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han …