The underlying pathology of bipolar disorder remains unknown, though evidence is
accumulating to support a role of mitochondrial dysfunction. In this study, we aim to …

Aim Though genetic factors play a major role in the pathophysiology of psychoses including
bipolar disorder (BD) and schizophrenia, lack of well‐established causative genetic …

ABSTRACT Introduction: Calcium channel blockers (CCBs) comprise a heterogeneous
group of medications that reduce calcium influx and attenuate cellular hyperactivity …

Objectives. Intracellular calcium (Ca2+) dyshomeostasis (ICDH) has been implicated in
bipolar disorder (BD) pathophysiology. We previously showed that SNP rs956572 in the B …

Bipolar disorder (BD) is a chronic psychiatric disorder of public health importance affecting>
1% of the Swedish population. Despite progress, patients still suffer from chronic mood …

The detection of changes in postsynaptic gene expression after the administration of mood
stabilizers, alone or in combination with antipsychotics, and antidepressants in animal …

Valproic acid (VLP) is a widely used anticonvulsant and mood-stabilizing drug that relieves
the endoplasmic reticulum (ER) stress response, a pathogenetic process related to diabetes …

Background Calcium voltage-gated channel auxiliary subunit β2 is a protein that, in humans,
is encoded by the CACNB2 gene. The β2 subunit is an auxiliary protein of voltage-gated …

Purpose Development of new thymoleptic medications has primarily centered on
anticonvulsants and antipsychotic drugs. Based on our studies of intracellular calcium ion …

Dysfunction of the noradrenergic (NE) neurons is implicated in the pathogenesis of bipolar
disorder (BPD). ErbB4 is highly expressed in NE neurons, and its genetic variation has been …