Irregularities of intracellular calcium (Ca2+) homeostasis have been implicated in the
pathophysiology of bipolar disorder (BD). Findings that chronic ex-vivo treatment with lithium …

The authors discuss the challenges of psychiatric nosology and diagnosis, relative to the
article by M. Aragona regarding study of subjective experience as a scientific work for …

The relevant scientific literature has accumulated an extensive array of data indicating the
neuroprotective potential of creatine (Cr). However, while many recent experimental and …

Objectives Transient receptor potential canonical type 3 (TRPC 3) channels are activated in
B lymphoblast cell lines from patients with bipolar disorder (BD), and its expression is …

The association between mental disorders and diabetes has a long history. Recent large-
scale, well-controlled epidemiological studies confirmed a link between diabetes and …

The anti-apoptotic protein Bax inhibitor-1 (BI-1) is a regulator of apoptosis linked to
endoplasmic reticulum (ER) stress. It has been hypothesized that BI-1 protects against …

Identifying the genetic basis of gene expression variation in the human brain is important for
understanding brain physiology and pathophysiology. We investigated the genetic basis of …

Abstract Objective: Wolfram syndrome (WS, MIM 222300) is a rare autosomal, recessive
neurodegenerative disorder associated with mutations in WFS1, a gene that has been …

Bipolar disorder is clinically characterized by fluctuating affect, and neuropsychologically by
impairment in executive functions. Such phenomena are consistent with the centrality of …

Altered intracellular calcium homeostasis and oxidative stress are involved in the
pathophysiology of bipolar disorder (BD)-I. To explore the genes contributing to these …