Drug development advances in human genetics‐based targets
X Zhang, W Yu, Y Li, A Wang, H Cao, Y Fu - MedComm, 2024 - Wiley Online Library
Drug development is a long and costly process, with a high degree of uncertainty from the
identification of a drug target to its market launch. Targeted drugs supported by human …
identification of a drug target to its market launch. Targeted drugs supported by human …
L-type calcium channels and neuropsychiatric diseases: Insights into genetic risk variant-associated genomic regulation and impact on brain development
MR Baker, AS Lee, AM Rajadhyaksha - Channels, 2023 - Taylor & Francis
Recent human genetic studies have linked a variety of genetic variants in the CACNA1C
and CACNA1D genes to neuropsychiatric and neurodevelopmental disorders. This is not …
and CACNA1D genes to neuropsychiatric and neurodevelopmental disorders. This is not …
Genetic evidence for the “dopamine hypothesis of bipolar disorder”
CY Zhang, X Cai, L Guo, L Wang, Z Liu, XJ Luo… - Molecular …, 2023 - nature.com
Bipolar disorder (BD) is a severe psychiatric illness characterized by recurrent episodes of
mania/hypomania and depression. Based on the investigations into the pathological and …
mania/hypomania and depression. Based on the investigations into the pathological and …
[HTML][HTML] Analysis of genetic diversity in patients with major psychiatric disorders versus healthy controls: A molecular-genetic study of 1698 subjects genotyped for 100 …
HH Stassen, S Bachmann, R Bridler, K Cattapan… - Psychiatry …, 2024 - Elsevier
Background This study analyzed the extent to which irregularities in genetic diversity
separate psychiatric patients from healthy controls. Methods Genetic diversity was quantified …
separate psychiatric patients from healthy controls. Methods Genetic diversity was quantified …
Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function
ZH Yang, X Cai, ZL Ding, W Li, CY Zhang, JH Huo… - BMC medicine, 2023 - Springer
Background Schizophrenia and bipolar disorder (BD) are believed to share clinical
symptoms, genetic risk, etiological factors, and pathogenic mechanisms. We previously …
symptoms, genetic risk, etiological factors, and pathogenic mechanisms. We previously …
[HTML][HTML] Chronic exposure to imipramine induces a switch from depression-like to mania-like behavior in female serotonin transporter knockout rats: Role of BDNF …
Background Bipolar disorder (BD) is a highly burdensome psychiatric disorder characterized
by alternating states of mania and depression. A major challenge in the clinic is the switch …
by alternating states of mania and depression. A major challenge in the clinic is the switch …
New “drugs and targets” in the GWAS era of bipolar disorder
Objective Due to the phenotypic heterogeneity and etiological complexity of bipolar disorder
(BD), many patients do not respond well to the current medications, and developing novel …
(BD), many patients do not respond well to the current medications, and developing novel …
[HTML][HTML] White matter integrity in bipolar disorder investigated with diffusion tensor magnetic resonance imaging and fractal geometry
L Squarcina, SL Paioni, M Bellani, MG Rossetti… - Journal of Affective …, 2024 - Elsevier
Background Growing evidence suggests the presence of white matter (WM) alterations in
bipolar disorder (BD). In this study we aimed to investigate the state of WM structures, in …
bipolar disorder (BD). In this study we aimed to investigate the state of WM structures, in …
[HTML][HTML] Lithium response in bipolar disorder: Epigenome-wide DNA methylation signatures and epigenetic aging
M Zafrilla-López, M Acosta-Díez, M Mitjans… - European …, 2024 - Elsevier
Lithium (Li) is the first-line treatment for bipolar disorder (BD) even though only 30% of BD
patients are considered excellent responders. The mechanisms by which Li exerts its action …
patients are considered excellent responders. The mechanisms by which Li exerts its action …
[HTML][HTML] Integrative analysis of transcriptome-wide association study and mRNA expression profile identified risk genes for bipolar disorder
R Yang, R Wang, D Zhao, K Lian, B Shang, L Dong… - Neuroscience …, 2024 - Elsevier
Objective Bipolar disorder (BD) is a debilitating neuropsychiatric disorder, which is
associated with genetic variation through “vast but mixed” Genome-Wide Association …
associated with genetic variation through “vast but mixed” Genome-Wide Association …