The importance of the kynurenine pathway in normal immune system function has led to an
appreciation of its possible contribution to autoimmune disorders such as rheumatoid …

Neurodegenerative diseases (NDs) are a diverse group of disorders characterized by the
progressive degeneration and death of neurons, leading to a range of neurological …

In recent years, striking new evidence has demonstrated non-genetic inheritance of
acquired traits associated with parental environmental exposures. In particular, this …

Simple Summary DNA methylation is an epigenetic modification of genes which affects
corresponding gene expression. During the developmental stage, embryonic stem cells …

Huntington's Disease (HD) is a hereditary neurodegenerative disorder caused by the
expansion of a CAG triplet repeat in the HTT gene, resulting in the production of an aberrant …

Methylation of cytosine in CpG dinucleotides is the major DNA modification in mammalian
cells that is a key component of stable epigenetic marks. This modification, which on the one …

Neurodegenerative movement disorders (NMDs) are age‐dependent disorders that are
characterised by the degeneration and loss of neurons, typically accompanied by …

Huntington's disease (HD) is a genetic, fatal autosomal dominant neurodegenerative
disorder typically occurring in midlife with symptoms ranging from chorea, to dementia, to …

Huntington disease (HD) is a degenerative brain disease caused by the expansion of CAG
(cytosine-adenine-guanine) repeats, which is inherited as a dominant trait and progressively …

DNA methyltransferases (DNMTs) are widely expressed in the brain, dictating the
transcriptional activity of genes through various epigenetic mechanisms. Functional …