Advances in epigenetics link genetics to the environment and disease
Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …
excitement and hope, but also a degree of hype. Here we review how the field has evolved …
[HTML][HTML] Epigenetic modifications in stress response genes associated with childhood trauma
Adverse childhood experiences (ACEs) may be referred to by other terms (eg, early life
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …
[HTML][HTML] A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches
Childhood maltreatment is a major risk factor for chronic and severe mental and physical
health problems across the lifespan. Increasing evidence supports the hypothesis that …
health problems across the lifespan. Increasing evidence supports the hypothesis that …
[HTML][HTML] Childhood maltreatment and DNA methylation: A systematic review
DNA methylation (DNAm)–an epigenetic process that regulates gene expression–may
represent a mechanism for the biological embedding of early traumatic experiences …
represent a mechanism for the biological embedding of early traumatic experiences …
[HTML][HTML] Epigenetics of childhood trauma: Long term sequelae and potential for treatment
KM Thumfart, A Jawaid, K Bright, M Flachsmann… - Neuroscience & …, 2022 - Elsevier
Childhood trauma (CT) can have persistent effects on the brain and is one of the major risk
factors for neuropsychiatric diseases in adulthood. Recent advances in the field of …
factors for neuropsychiatric diseases in adulthood. Recent advances in the field of …
[HTML][HTML] Developmental programming of oxytocin through variation in early-life stress: Four meta-analyses and a theoretical reinterpretation
Despite evidence supporting a role for oxytocin (OT) in regulating social behavior,
surprisingly little is known about how this neuropeptide is calibrated during development …
surprisingly little is known about how this neuropeptide is calibrated during development …
[HTML][HTML] Glucocorticoid signaling and epigenetic alterations in stress-related disorders
Stress is defined as a state of threatened or perceived as threatened homeostasis. The well-
tuned coordination of the stress response system is necessary for an organism to respond to …
tuned coordination of the stress response system is necessary for an organism to respond to …
[HTML][HTML] Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression
Background The neuropeptide oxytocin regulates mammalian social behavior. Disruptions
in oxytocin signaling are a feature of many psychopathologies. One commonly studied …
in oxytocin signaling are a feature of many psychopathologies. One commonly studied …
Epigenetic modification of the oxytocin receptor gene: implications for autism symptom severity and brain functional connectivity
E Andari, S Nishitani, G Kaundinya… - …, 2020 - nature.com
The role of oxytocin in social cognition has attracted tremendous interest in social
neuroscience and psychiatry. Some studies have reported improvement in social symptoms …
neuroscience and psychiatry. Some studies have reported improvement in social symptoms …
[HTML][HTML] Genes and aggressive behavior: epigenetic mechanisms underlying individual susceptibility to aversive environments
S Palumbo, V Mariotti, C Iofrida… - Frontiers in behavioral …, 2018 - frontiersin.org
Over the last two decades, the study of the relationship between nature and nurture in
shaping human behavior has encountered a renewed interest. Behavioral genetics showed …
shaping human behavior has encountered a renewed interest. Behavioral genetics showed …