Alternative splicing regulatory networks: functions, mechanisms, and evolution

J Ule, BJ Blencowe - Molecular cell, 2019 - cell.com
High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …

Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology

C Cheroni, N Caporale, G Testa - Molecular autism, 2020 - Springer
The complex pathophysiology of autism spectrum disorder encompasses interactions
between genetic and environmental factors. On the one hand, hundreds of genes …

Genetic advances in autism

A Thapar, M Rutter - Journal of autism and developmental disorders, 2021 - Springer
In the last 40 years, there has been a huge increase in autism genetics research and a
rapidly growing number of discoveries. We now know autism is one of the most highly …

Benefits of curcumin in brain disorders

A Bhat, AM Mahalakshmi, B Ray, S Tuladhar… - …, 2019 - Wiley Online Library
Curcumin is widely consumed in Asia either as turmeric directly or as one of the culinary
ingredients in food recipes. The benefits of curcumin in different organ systems have been …

The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts

P Kjer-Hansen, RJ Weatheritt - Nature Structural & Molecular Biology, 2023 - nature.com
Alternative splicing affects more than 95% of multi-exon genes in the human genome. These
changes affect the proteome in a myriad of ways. Here, we review our understanding of the …

Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9–Cas12a platform

T Gonatopoulos-Pournatzis, M Aregger… - Nature …, 2020 - nature.com
Systematic mapping of genetic interactions (GIs) and interrogation of the functions of sizable
genomic segments in mammalian cells represent important goals of biomedical research. To …

Augmented reality, serious games and picture exchange communication system for people with ASD: systematic literature review and future directions

H Almurashi, R Bouaziz, W Alharthi, M Al-Sarem… - Sensors, 2022 - mdpi.com
For people with Autism Spectrum Disorder (ASD), using technological tools, such as
augmented reality (AR) and serious games remain a new and unexplored option. To attract …

Correlation of gut microbiome between ASD children and mothers and potential biomarkers for risk assessment

N Li, J Yang, J Zhang, C Liang, Y Wang… - Genomics …, 2019 - academic.oup.com
Variation of maternal gut microbiota may increase the risk of autism spectrum disorders
(ASDs) in offspring. Animal studies have indicated that maternal gut microbiota is related to …

Autism-misregulated eIF4G microexons control synaptic translation and higher order cognitive functions

T Gonatopoulos-Pournatzis, R Niibori, EW Salter… - Molecular cell, 2020 - cell.com
Microexons represent the most highly conserved class of alternative splicing, yet their
functions are poorly understood. Here, we focus on closely related neuronal microexons …