Pancreatic islet transplantation in humans: recent progress and future directions

MR Rickels, RP Robertson - Endocrine reviews, 2019 - academic.oup.com
Pancreatic islet transplantation has become an established approach to β-cell replacement
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …

Defining outcomes for β‐cell replacement therapy in the treatment of diabetes: a consensus report on the Igls criteria from the IPITA/EPITA opinion leaders workshop

MR Rickels, PG Stock, EJP De Koning… - Transplant …, 2018 - Wiley Online Library
Summary β‐cell replacement therapy, available currently as pancreas or islet
transplantation, has developed without a clear definition of graft functional and clinical …

Phase 3 trial of transplantation of human islets in type 1 diabetes complicated by severe hypoglycemia

BJ Hering, WR Clarke, ND Bridges… - Diabetes …, 2016 - Am Diabetes Assoc
OBJECTIVE Impaired awareness of hypoglycemia (IAH) and severe hypoglycemic events
(SHEs) cause substantial morbidity and mortality in patients with type 1 diabetes (T1D) …

[图书][B] Basic transport phenomena in biomedical engineering

RL Fournier - 2017 - taylorfrancis.com
This will be a substantial revision of a good selling text for upper division/first graduate
courses in biomedical transport phenomena, offered in many departments of biomedical and …

Navigating two roads to glucose normalization in diabetes: automated insulin delivery devices and cell therapy

E Latres, DA Finan, JL Greenstein, A Kowalski… - Cell metabolism, 2019 - cell.com
Incredible strides have been made since the discovery of insulin almost 100 years ago.
Insulin formulations have improved dramatically, glucose levels can be measured …

Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes

B Ludwig, S Ludwig, A Steffen… - Proceedings of the …, 2017 - National Acad Sciences
Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with
critical metabolic lability resulting from the need for immunosuppression and the shortage of …

[HTML][HTML] Encapsulated islet transplantation: where do we stand?

V Vaithilingam, S Bal, BE Tuch - The review of diabetic studies …, 2017 - ncbi.nlm.nih.gov
Transplantation of pancreatic islets encapsulated within immuno-protective microcapsules is
a strategy that has the potential to overcome graft rejection without the need for toxic …

Will genetic engineering carry xenotransplantation of pig islets to the clinic?

E Kemter, J Denner, E Wolf - Current diabetes reports, 2018 - Springer
Abstract Purpose of Review Porcine islets represent a potentially attractive beta-cell source
for xenotransplantation into patients with type 1 diabetes, who are not eligible to islet allo …

Pig-to-primate islet xenotransplantation: past, present, and future

Z Liu, W Hu, T He, Y Dai, H Hara, R Bottino… - Cell …, 2017 - journals.sagepub.com
Islet allotransplantation results in increasing success in treating type 1 diabetes, but the
shortage of deceased human donor pancreata limits progress. Islet xenotransplantation …

Genetically modified pigs as donors of cells, tissues, and organs for xenotransplantation

E Wolf, E Kemter, N Klymiuk, B Reichart - Animal Frontiers, 2019 - academic.oup.com
Genetically modified pigs as donors of cells, tissues, and organs for xenotransplantation |
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