The emerging role of epigenetic therapeutics in immuno-oncology
MJ Topper, M Vaz, KA Marrone, JR Brahmer… - Nature Reviews …, 2020 - nature.com
The past decade has seen the emergence of immunotherapy as a prime approach to cancer
treatment, revolutionizing the management of many types of cancer. Despite the promise of …
treatment, revolutionizing the management of many types of cancer. Despite the promise of …
Translating the histone code
T Jenuwein, CD Allis - Science, 2001 - science.org
Chromatin, the physiological template of all eukaryotic genetic information, is subject to a
diverse array of posttranslational modifications that largely impinge on histone amino …
diverse array of posttranslational modifications that largely impinge on histone amino …
Epigenetics in human disease and prospects for epigenetic therapy
Epigenetic mechanisms, which involve DNA and histone modifications, result in the
heritable silencing of genes without a change in their coding sequence. The study of human …
heritable silencing of genes without a change in their coding sequence. The study of human …
Chromosome territories, nuclear architecture and gene regulation in mammalian cells
The expression of genes is regulated at many levels. Perhaps the area in which least is
known is how nuclear organization influences gene expression. Studies of higher-order …
known is how nuclear organization influences gene expression. Studies of higher-order …
Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell
HM Kagan, W Li - Journal of cellular biochemistry, 2003 - Wiley Online Library
Lysyl oxidase (LO) plays a critical role in the formation and repair of the extracellular matrix
(ECM) by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of …
(ECM) by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of …
Histone methylation versus histone acetylation: new insights into epigenetic regulation
JC Rice, CD Allis - Current opinion in cell biology, 2001 - Elsevier
Post-translational addition of methyl groups to the amino-terminal tails of histone proteins
was discovered more than three decades ago. Only now, however, is the biological …
was discovered more than three decades ago. Only now, however, is the biological …
Epigenetics—an epicenter of gene regulation: histones and histone‐modifying enzymes
M Biel, V Wascholowski… - Angewandte Chemie …, 2005 - Wiley Online Library
The treatment of cancer through the development of new therapies is one of the most
important challenges of our time. The decoding of the human genome has yielded important …
important challenges of our time. The decoding of the human genome has yielded important …
HLA-G molecules: from maternal-fetal tolerance to tissue acceptance.
ED Carosella, P Moreau, J Le Maoult… - Advances in …, 2003 - europepmc.org
Over the past few years, HLA-G, the non-classical HLA class I molecule, has been the center
of investigations that have led to the description of its specific structural and functional …
of investigations that have led to the description of its specific structural and functional …
Histone deacetylation in epigenetics: an attractive target for anticancer therapy
The reversible histone acetylation and deacetylation are epigenetic phenomena that play
critical roles in the modulation of chromatin topology and the regulation of gene expression …
critical roles in the modulation of chromatin topology and the regulation of gene expression …
Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells
L Pirola, A Balcerczyk, RW Tothill, I Haviv… - Genome …, 2011 - genome.cshlp.org
Emerging evidence suggests that poor glycemic control mediates post-translational
modifications to the H3 histone tail. We are only beginning to understand the dynamic role of …
modifications to the H3 histone tail. We are only beginning to understand the dynamic role of …