High altitude illness in its most severe form can lead to high altitude cerebral edema
(HACE). Current strategies have focused on prevention with graduated ascents …

Background Several neurological conditions might worsen with the exposure to high altitude
(HA). The aim of this review was to summarize the available knowledge on the neurological …

Background High-altitude cerebral edema (HACE) is a serious and potentially fatal brain
injury that is caused by acute hypobaric hypoxia (HH) exposure. Vasogenic edema is the …

To provide guidance to clinicians about best practices, the Wilderness Medical Society
(WMS) convened an expert panel to develop evidence-based guidelines for prevention …

Background Neuroinflammation caused by peripheral lipopolysaccharides (LPS) under
hypoxia is a key contributor to the development of high altitude cerebral edema (HACE). Our …

Severe acute mountain sickness (sAMS) can be life-threatening, but little is known about its
genetic basis. The study was aimed to explore the genetic susceptibility of sAMS for the …

As human spaceflight progresses with extended mission durations, the demand for effective
and safe drugs will necessarily increase. To date, the accepted medications used during …

Mountaineering and exposure to high altitude result in physiological adaptations to the
reduced inspiratory oxygen availability. Acute mountain sickness (AMS), high altitude …

Human Acclimatization and therapeutic approaches are the core components for
conquering the physiological variations at high altitude (≥ 2500 m) exposure. The declined …

With the advancement of in vivo magnetic resonance imaging (MRI) technique, more
detailed information about the human brain at high altitude (HA) has been revealed. The …