The oocyte is recognised as the largest cell in mammalian species and other multicellular
organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and …

As women delay childbearing because of demographic and socioeconomic trends,
reproductive aging and ensuing ovarian dysfunction become increasingly more prevalent …

Primary mitochondrial disease (PMD) is a group of complex genetic disorders that arise due
to pathogenic variants in nuclear or mitochondrial genomes. Although PMD is one of the …

In recent years increasing numbers of women from wealthy countries have turned to egg
donation, egg freezing, and in vitro fertilization to become pregnant, especially later in life …

O presente artigo busca analisar o conceito de biopoder, tal como elaborado por Michel
Foucault, entre os anos de 1974 e 1979. O biopoder é definido como assumindo duas …

With the advent of efficient, easy-to-use genome editing by CRISPR–Cas9, editing human
embryos is now possible, providing tremendous opportunities to study gene function and …

Mitochondria have been implicated as key factors regulating female reproductive processes.
Notable progress has been made in determining the role of mitochondria with respect to …

Mitochondrial disorders are among the most common inborn errors of metabolism; at least
15% are caused by mitochondrial DNA (mtDNA) mutations, which occur de novo or are …

Ovarian reserve is essential for fertility and influences healthy aging in women. Advanced
maternal age correlates with the progressive loss of both the quantity and quality of oocytes …

Mitochondria transfer techniques were first designed to prevent the transmission of diseases
due to mutations in mtDNA, as these organelles are exclusively transmitted to the offspring …